A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae

It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2002

Author dc:creator

• Coert, Claudette

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/4250

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/4250