{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/4250"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/4250","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae","abstract":"It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity.","abstract_html":"It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity.","abstract_has_math":false,"creators":["Coert, Claudette"],"institution":"Department of Molecular and Cell Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-22T22:23:00Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/4250","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Coert, Claudette"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-30T17:36:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-30T17:36:15Z"]},{"key":"dc:date.issued","label":"Date","values":["2002"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Molecular and Cell Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/4250"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: leaves 90-111."]},{"key":"dc:description.abstract","label":"Abstract","values":["It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity."]},{"key":"dc:title","label":"Title","values":["A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae"]}]}],"canonical_facts":{"dc:creator":["Coert, Claudette"],"dc:date.accessioned":["2014-07-30T17:36:15Z"],"dc:date.available":["2014-07-30T17:36:15Z"],"dc:date.issued":["2002"],"dc:description":["Bibliography: leaves 90-111."],"dc:description.abstract":["It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity."],"dc:identifier.uri":["http://hdl.handle.net/11427/4250"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Molecular and Cell Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:00Z"}