The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also inactivates the vasodilator bradykinin. The main overall effect of these actions is an increase in blood pressure. Several ACF inhibitors have been developed as drugs for the treatment of myocardial infarction, hypertension, kidney failure and heart failure.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2006

Author dc:creator

• Chitapi, Itai

Advisors dc:contributor.advisor

• Sewell, Bryan Trevor
• Sturrock, E D

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/4248

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/4248