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Showing 1 to 20 of 21 for “"TACE"”.

  1. The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

    Chitapi, ItaiDepartment of Molecular and Cell Biology2006

    Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin II, a potent vasoconstrictor. By the same enzymatic mechanism, ACE also …

    cape-town Repository record

  2. Optimización de la selección de pacientes con carcinoma hepatocelular a tratamiento con quimioembolización transarterial hepática (TACE)

    Pipa Muñiz, María2021

    … es la quimioembolización transarterial hepática (TACE). Además de estos pacientes, tumores en estadio más precoz no candidatos a opciones curativas pueden igualmente recibir este tratamiento siguiendo lo que se denomina la “migración terapéutica”. Desde 2007 se ha incorporado la TACE con …

    oviedo Repository record

  3. Influence of Preoperative Transcatheter Arterial Chemoembolization on Gene Expression in the HIF-1α Pathway in patients with Hepatocellular Carcinoma

    XU, WEIGUANG2015

    … transcatheter arterial chemoembolization (TACE) is the most common treatment option in patients with hepatocellular carcinoma (HCC), its clinical benefits remain still controversial. Since TACE induces hypoxic necrosis in tumors, hypoxia-inducible factor 1α (HIF-1α) could …

    ajou Repository record

  4. Human testis angiotensin-converting enzyme: crystal structure of a glycosylation mutant and investigation of a putative hinge-mechanism by normal mode analysis

    Watermeyer, Jean MargaretUniversity of the Western Cape2004

    … of crystal structures of human testis ACE (tACE), and homologues Drosophila AnCE and human ACE2. tACE is identical to the C-terminal domain of somatic ACE, which consists of two homologous domains, each having a slightly different substrate-specificity. This thesis describes the …

    western-cape Repository record

  5. Retrospective study at a single tertiary hospital in South Africa (Groote Schuur) on the treatment outcome in patients who underwent TransArterial Chemo-Embolization (TACE) for hepatocellular carcinoma

    Sihlahla, IrvineDivision of Radiology2022

    … options. Transarterial chemoembolisation (TACE) is an option widely reported and used for palliative care and as a bridge to liver transplantation. Limited South African studies have examined the outcome of this type of therapy, with one comparing survival benefit and hospital stays in TACE …

    cape-town Repository record

  6. The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma

    Cox, JosiahUniversity of Kansas2016

    Trans-arterial chemoembolization (TACE) with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor …

    ku Repository record

  7. A Molecular Basis for the C-Domain Selectivity of Angiotensin-Converting Enzyme

    Kroger, WDivision of Medical Biochemistry2009

    … domains, N- and C-domain, and testisACE (tACE), corresponding to the C-domain of sACE. Despite a high degree of sequenceidentity, these two domains display marked differences in substrate and inhibitor specificity.Furthermore, the C-domain of ACE has been implicated to play a dominant role …

    cape-town Repository record

  8. 간세포암 환자의 치료에 있어 수술적 절제술과 간동맥 화학색전술 치료요법에 따른 생존율 비교 연구

    이, 광현2011

    … with transcatheter arterial chemoembolization (TACE) which was a non-operative method were investigated and compared. Further, statistical significances in the survival periods were examined by controlling prognostic factors affecting the survival rates of the patients with hepatocellular …

    ajou Repository record

  9. Development of Multifunctional Drug Delivery Systems for Locoregional Therapy

    Li, XinyiThe University of Western Ontario2021

    … effective. For transarterial chemoembolization (TACE) therapy of hepatocellular carcinoma (HCC), the most current approaches do not allow repeat treatment as the drug delivery vehicle is not degradable. In addition, image contrast agents for visualization are administered separately, leading to …

    uwo Repository record

  10. Characterisation of the structural motifs Involved in the cleavage and secretion of human angiotensin-converting enzyme

    Conrad, NailahDivision of Medical Biochemistry2014

    … and physiological processes. Testis ACE (tACE) is shed at a higher rate than somatic ACE and it has been proposed that regions in its ectodomain direct its shedding. Discrete secondary structures on the surface of the distal ectodomain of tACE were replaced with their N-domain counterparts …

    cape-town Repository record

  11. Mechanisms of chloride modulated activity in the C-domain of angiotensin-converting enzyme

    Yates, Christopher JohnDivision of Medical Biochemistry2012

    … Chloride binding in the chloride 1 pocket of tACE was found to affect positioning of K511 and potentially alter the conformation of the active site. This would alter C-terminal substrate interactions, which were suggested to affect chloride 2 pocket ion affinity by coordinating Y520 and affect …

    cape-town Repository record

  12. Molecular Players in Lupus: Leads from Proteomic Screens

    Orme, Jacob Jennings2018

    … CD11b+/CD14+ leukocytes by proteases ADAM10 and TACE (ADAM17) to abrogate macrophage anti-inflammatory signaling through Twist. I further find that β-catenin is dysregulated in SLE but the deletion of β-catenin in lupus-prone macrophages does not appreciably change disease course. Lastly, I find …

    utswmed Repository record

  13. The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons

    Escobedo, Cassandra MarieEastern Kentucky University

    … by Tumor Necrosis Factor converting enzyme (TACE) and γ-secretase has been observed to be associated with an increase in neurodegeneration. In a previous study, p75NTR was discovered to become activated in sympathetic neurons in response to oxidative stress induced by 4-hydroxynonenal (HNE) …

    eku Repository record

  14. Clinical and Pathologic Characteristics of Hepatocellular Carcinoma following Resection according to the Tumor Size

    조, 성연, 최, 진혁2011

    … transcatheter arterial chemoembolization (TACE). The 307 patients’ clinicopathologic data were retrospectively investigated. The tumor size criteria (2cm, 5cm and 10cm) were predictive factors for survival in univariate analysis, but not in multivariate analysis. Vascular invasion, tumor …

    ajou Repository record

  15. Terapia locorregional combinada en pacientes cirróticos con hepatocarcinoma atendidos en un centro de referencia en Colombia entre 2020-2024

    Bernal Vaca, María Lucía, Piñeros Nieto, Diego Alejandro, Beltrán, OscarUniversidad del Rosario2025

    Introducción: En hepatocarcinoma, las terapias TACE y ablación tienen eficacia limitada en monoterapia. Evidencia reciente sugiere que combinadas son seguras, potencian ventajas de cada una superando las limitaciones y amplían el efecto, especialmente para lesiones grandes o múltiples. Métodos: …

    rosario Repository record

  16. Characterization of the Rank Ligand Positive Giant Cell Found in the Interfacial Membrane

    Jones, Patrick Emerson2014

    … high concentrations of TNF-a converting enzyme (TACE). These data lead to a hypothesis as to how this cell might form and how large an impact it might play in the interfacial membrane with respect to aseptic bone reabsorption.

    vcu Repository record

  17. Neural and Physical Niches Orchestrate Skeletal Remodelling and Promote Cartilage Regeneration

    Gadomski, StephenUniversity of Cambridge2023

    … tumour necrosis factor-alpha converting enzyme (TACE) in neurons, which promotes cleavage of IL-6 receptor leading to enhanced <i>trans</i>-IL-6 signalling, reducing cholinergic trans-differentiation. Therefore, during postnatal life, sprouting sympathetic neurons contact the periosteum and …

    cambridge Repository record

  18. La disciplina legale dell'amministrazione di s.r.l.: funzionamento del c.d.a. e invalidità delle decisioni gestorie

    CANNAO', GRAZIELLAUniversità degli studi di Catania2016

    … collegiale. Allo stesso modo, il codice tace in ordine alla disciplina delle eventuali invalidità delle decisioni degli amministratori (sia del c.d.a., sia dell’amministratore unico) e delle conseguenti impugnative, salvo che nell art.2475-ter c.c., per quel che riguarda le deliberazioni …

    catania Repository record

  19. Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein

    Scherm, MichaelUniversity of Cambridge2021

    … following proteolytic cleavage of GP1,2 by TACE protease at the virion membrane. Shed GP migrates through the bloodstream to remote tissues, activating innate immune cells leading to host-wide cytokine storms. The innate immune receptor Toll-like receptor 4, a pattern-recognition receptor …

    cambridge Repository record

  20. Synthesis and Characterization of Polymeric Materials as Sequestrants for Biological Applications

    Wadsworth, Ophelia JuanitaVirginia Tech2025

    To address the systemic toxicity attributable to doxorubicin (Dox) following targeted chemotherapy treatments for hepatocellular carcinoma, we explored drug-capture strategies using both DNA-functionalized substrates and synthetic polymeric materials. DNA-modified cotton substrates were prepared …

    vt Repository record

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