The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome

In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events.

Grantor

Department of Medicine

Year dc:date.issued

2022

Author dc:creator

• Stek, Cari

Advisors dc:contributor.advisor

• Meintjes, Graeme
• Shey Muki

• lung function

Handle dc:identifier.uri

http://hdl.handle.net/11427/41559

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/41559