{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/41559"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/41559","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome","abstract":"In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events.","abstract_html":"In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events.","abstract_has_math":false,"creators":["Stek, Cari"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Meintjes, Graeme","Shey Muki"],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022","date_published":"2022","updated_at":"2026-07-22T22:23:04Z","subjects":["lung function"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/41559","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Meintjes, Graeme","Shey Muki"]},{"key":"dc:creator","label":"Author","values":["Stek, Cari"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-08-08T11:25:34Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-08-08T11:25:34Z"]},{"key":"dc:date.issued","label":"Date","values":["2022"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:type","label":"Dc Type","values":["Thesis / Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral","PhD"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["lung function"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/41559"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events."]},{"key":"dc:title","label":"Title","values":["The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome"]}]}],"canonical_facts":{"dc:contributor.advisor":["Meintjes, Graeme","Shey Muki"],"dc:creator":["Stek, Cari"],"dc:date.accessioned":["2025-08-08T11:25:34Z"],"dc:date.available":["2025-08-08T11:25:34Z"],"dc:date.issued":["2022"],"dc:description.abstract":["In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events."],"dc:identifier.uri":["http://hdl.handle.net/11427/41559"],"dc:publisher.department":["Department of Medicine"],"dc:subject":["lung function"],"dc:title":["The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome"],"dc:type":["Thesis / Dissertation"],"dc:type.qualificationlevel":["Doctoral","PhD"]},"updated_at":"2026-07-22T22:23:04Z"}