Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy

The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2007

Author dc:creator

• Zungu, Makhosazane

Advisor dc:contributor.advisor

• Essop, M Faadiel

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3498

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3498