{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3498"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3498","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy","abstract":"The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. 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The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV."]},{"key":"dc:title","label":"Title","values":["Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy"]}]}],"canonical_facts":{"dc:contributor.advisor":["Essop, M Faadiel"],"dc:creator":["Zungu, Makhosazane"],"dc:date.accessioned":["2014-07-29T09:38:49Z"],"dc:date.available":["2014-07-29T09:38:49Z"],"dc:date.issued":["2007"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. 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