The role of IL-4Ra during acute schistosomiasis

During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2006

Author dc:creator

• Leeto, Mosiuoa

Advisor dc:contributor.advisor

• Brombacher, Frank

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3416

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3416