{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/3416"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/3416","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of IL-4Ra during acute schistosomiasis","abstract":"During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.","abstract_html":"During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.","abstract_has_math":false,"creators":["Leeto, Mosiuoa"],"institution":"Department of Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Brombacher, Frank"],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-22T22:23:00Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/3416","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Brombacher, Frank"]},{"key":"dc:creator","label":"Author","values":["Leeto, Mosiuoa"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-29T09:06:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-29T09:06:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/3416"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology."]},{"key":"dc:title","label":"Title","values":["The role of IL-4Ra during acute schistosomiasis"]}]}],"canonical_facts":{"dc:contributor.advisor":["Brombacher, Frank"],"dc:creator":["Leeto, Mosiuoa"],"dc:date.accessioned":["2014-07-29T09:06:30Z"],"dc:date.available":["2014-07-29T09:06:30Z"],"dc:date.issued":["2006"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology."],"dc:identifier.uri":["http://hdl.handle.net/11427/3416"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of IL-4Ra during acute schistosomiasis"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:00Z"}