Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species

Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that TNFa-induced cytoprotection requires the generation of ROS. In addition, it was postulated that this ROS generation originates in the mitochondria.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2005

Author dc:creator

• Lacerda, Lydia

Advisors dc:contributor.advisor

• Lecour, Sandrine
• Opie, Lionel H

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3414

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3414