Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 458 for “"signalling pathways"”.
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… coordinated intercellular communication via signalling pathways, mechanisms underlying intestinal morphogenesis remain unclear. The Hedgehog signalling pathway is critical for many aspects of gut development, however, its downstream transcriptional targets allowing for complex cell behaviours …
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Regulation of neutrophilic inflammation by hypoxic signalling pathways
… response. Close links exist between the pathways which regulate hypoxic and inflammatory responses. Our group has previously found that in mouse models of infection, acute hypoxia leads to increased sickness and that this is driven by neutrophilic inflammation. I have used a murine model …
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Suppression of pro-inflammatory signalling pathways by sulforaphane
… whether SF was able to suppress pro-inflammatory signalling using in vitro models of chronic inflammation. In human monocytes (PBMCs and THP-1 cells), physiologically relevant concentrations of SF significantly suppressed the production of LPS-induced cytokines IL-6, IL-1β and TNFα. The …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… action of a diverse set of intracellular signalling proteins. The Ras/Raf/MEK/MAPK signalling pathway has been shown to control the expression of genes which are crucial for the physiological regulation of cell proliferation, differentiation and apoptosis. Within this signalling cascade, …
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Determining the Signalling Pathways that Govern Human Naive Pluripotency
… stem cells (hESCs) rely on FGF and TGFβ signalling for self-renewal, and occupy a developmentally advanced state of pluripotency comparable to mouse EpiSCs. Recent reports demonstrate that a naïve state of human pluripotency can be consistently derived either through transient histone …
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Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
Aberrant regulation of the Wnt signalling pathway is a recurrent theme in cancer biology. Hyper activation due to oncogenic mutations and paracrine activity has been found in both colon cancer and breast cancer, and continues to evolve as a central mechanism in oncogenesis. PDLIM2, a cytoskeletal …
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Investigating temperature signalling pathways in Arabidopsis thaliana using small molecules
… importance to better understand temperature signalling pathways in plants in order to find solutions to this problem. In this thesis, a chemical genomics screen for molecules activating or repressing heat-inducible genes in A. thaliana was performed in collaboration with Syngenta and the …
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Cellular signalling pathways involved in muscle atrophy in cancer cachexia
Cancer cachexia encompases severe weight loss, characterised by the debilitating atrophy of adipose and skeletal muscle mass. Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF …
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Regulation of Wnt signalling pathways by the Dishevelled DEP domain
… receptors to trigger canonical and noncanonical signalling responses that control cell fates during animal development and tissue homeostasis. All Wnt signals are relayed by the hub protein Dishevelled (DVL). During canonical (β-catenin dependent) signalling, Dishevelled assembles signalosomes …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… there is limited knowledge regarding which signalling pathways act to control both the inflammatory response and macrophage efflux that allows tissue homeostasis to resume within the peripheral nerves. This thesis aims to investigate the expression pattern and distinct function of VIP and …
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Regulation of β2-integrins by signalling pathways and cytoplasmic interacting partners
… adhesion is important for leukocyte trafficking, signalling, activation and effector functions, but how integrin-mediated adhesion is regulated in leukocytes is still incompletely understood. The main focus of this thesis was to investigate signalling pathways and mechanisms which regulate …
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Spatiotemporal modeling and model restructuration approaches in studies of intracellular signalling pathways
… the complex phenomena of cell transduction pathways and cell biology in a single cell. Mathematical modeling and experimental evaluation are widely used approaches for this kind of research. Firstly, A multiscale framework for protein-protein interaction has been established using Brownian …
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Understanding the intracellular signalling pathways activated by lipid nanoparticle delivery of mRNA
… response and key triggers of innate immune signalling remain undefined. Therefore, the aim of this research was to investigate whether LNP/mRNA induces inflammation through Toll Like Receptors (TLRs) and whether endoplasmic reticulum (ER) stress is activated due to additional protein …
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Identification of signalling pathways regulating TBX2 gene expression and its target genes
… characterised and very little is known of the signalling pathways that regulate their expression and activity. The broad aim of this study was therefore to contribute towards the identification of Tbx2 target genes as well as to identify signalling pathways that regulate TBX2 expression. The …
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
… ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely understood. One potential protective pathway involves the generation of reactive oxygen species (ROS), which are known to be activated by TNFa. It was therefore hypothesized that …
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Cellular signalling pathways involved in thermoprotection of neural ciruit function in the locust.
… (OA/cAMP/PKA) and nitrergic (NO/cGMP/PKG) signalling pathways and tested their involvement in conferring thermotolerance to the vCPG during heat stress. I found that long applications of octopamine, or increased adenylate cyclase activity generated vCPG thermotolerance and was dependent …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
… quiescence, specifically the role of host cell signalling and translation initiation during reactivation from a non productive state. To achieve these objectives, a new system was established to study HSV-1 quiescence. The system employs the use of serum starved and temperature elevated primary …
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