Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women

The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2013

Author dc:creator

• Joffe, Yael

Advisors dc:contributor.advisor

• Goedecke, Julia
• Collins, Malcolm
• Van der Merwe, Lize

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3253

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3253