Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"TNFa"”.
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Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning
Ischaemic postconditioning (IPostC) is a powerful protective mechanism that activates prosurvival intrinsic signalling cascades to limit reperfusion injury but the exact signalling pathway involved in this cardioprotective effect still remains unclear.
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The production and characterization of a putative anti-idiotypic antibody to tumor necrosis factor-α
Tumor necrosis factor-a (TNFa) is primarily a macrophagederived cytokine. TNFa, in vitro, kills or inhibits growth of approximately one third of surveyed transformed cell lines dincluding the L929 and WEHI 164 murine fibrosarcoma cell lines. Very little is known about the mechanisms of TNFa action. …
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be toxic in PC12 cells. Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this …
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Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression
<p>Proinflammatory cytokine TNFa plays critical roles in promoting malignant cell proliferation, angiogenesis, and tumor metastasis in many cancers. However, the mechanism of TNFa-mediated tumor development remains unclear. Here, we show that IKKa, an important downstream kinase of TNFa, interacts …
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Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women
… thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported …
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Transport of proteins, biopharmaceuticals and small pharmaceutical compounds into normal and injured cartilage by Sangwon Byun.
… of mechanical injury and inflammatory cytokines, TNFa, on the uptake of anti-IL-6 antibody Fab fragment (48 kDa). Anti-IL-6 Fab was able to penetrate into cartilage, though final equilibrium uptake would likely occur only after 6-10 days within 1 mm thick explant disks. Uptake of anti-IL-6 Fab was …
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In vitro models of cartilage degradation following joint injury : mechanical overload, inflammatory cytokines and therapeutic approaches
… pro-inflammatory cytokines, such as TNFa and IL-6, have been implicated to play important roles in the pathogenesis of OA. We have used in vitro models of cartilage injury to examine the interplay between mechanical and cytokine-mediated pathways and to identify processes associated …
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Investigating the use of omega three fish oils as protective agents against cytokine-induced skeletal muscle damage
… Our group showed ERA protection fromcytokine (TNFa) induced muscular atrophy in a murine cell model (Magee et al2008). Further, ERA may have intracellular signaling component interactions and bedependent on PPARy (Magee et al 2012). ERA and DMA interact with lipid rafts (Liet al 2005) therefore …
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Klonierung der cDNA des Protein A Kinase-Adaptor-Proteins-2 und Untersuchungen zur Regulation seiner mRNA in humanen fötalen Osteoblasten
… werden.Das Maximum der Induktion sowohl durch TNFa als auch durch TPA erfolgt nach fünf Stunde, v.a. durch veränderte Transskription. Dies entspricht der Kinetik eines sogenannten schnell induzierbaren Gens. Beide Stoffe wirken u.a. über den Transkriptionsfaktor NFkB. Andere Faktoren wie die …
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Type 2 diabetes in Sri Lanka : Genetic epidemiology and periodontal association.
… the role of cytokine polymorphisms PAG and TNFA (-308) in association with periodontitis in people with type 2 diabetes.Family history data for one thousand patients was collected and analyzed. Subjects with established diabetes were recruited to the periodontal study (n=285) with an age and …
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Tuberculosis, Anaemia and Erythropoietin: a study evaluating the role of erythropoietin in the pathophysiology of the anaemia of tuberculosis
… the effect of tumour necrosis factor alpha (TNFa) produced by activated macrophages in PTB patients on Epo production in vitro. Furthermore, the mechanism involved in Epo gene expression was investigated. Haematological and biochemical parameters (including serum iron and Epo) were I studied …
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Μελέτη προφλεγμονωδών και αντιφλεγμονωδών κυτταροκινών σε ασθενείς με ισχαιμικό αγγειακό εγκεφαλικό επεισόδιο
… κυτταροκινών (IL4-589C>T, IL10-1082G>A, TNFa-308G>A, IL6-174G>C και IL12B 1188A>C) σε 145 διαδοχικούς ασθενείς με οξύ Ι-ΑΕΕ και ισάριθμους μάρτυρες. Επιπρόσθετα, η μελέτη αξιολόγησε το ρόλο της αντιφλεγμονώδους κυτταροκίνης αντιπονεκτίνης στην οξεία φάση του Ι-ΑΕΕ, καθώς και την πιθανή …
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Investigating the role of intra- and extra-cellular modulators of the transcription factor NF-kappaB
… inflammatory genes in response to TNFa stimulation. To study the role of extracellular modulators on the apoptotic behaviors of cells, a panel of human immortalized and cancer liver cell lines were pre-treated with pro-inflammatory cytokines TNFa and IL-1a followed by TRAIL, a …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
… assay, we found that macrophage-released TNFa and TGF1 enhance cancer cell migration speed and persistence in 3D ECM in an MMP-dependent fashion via two distinct pathways. Specifically, macrophagereleased TGF1 enhances cancer cell migration speed via the induction of MTl-MMP expression in …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
… in the contact hypersensitivity (CH) response. TNFaR knockout mice exposed to cUCA displayed 33.9% greater ear swelling than cUCA-exposed wild-type C57BL/6N mice, suggesting that increased TNFa may be involved in inhibited CH by cUCA. TNFaR knockout mice exposed to permethrin displayed 33.9% …
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Role of Chitinase in the development of work-related symptoms in bakery workers
… 측정하였다. 혈청내 Chitinase측정과 함께 혈청내 TNFa, IL-18, MPO치도 ELISA 로 측정하였다. 또한 선천성 면역 반응과의 연관성을 관찰하기 위하여, 두 가지 Toll 유사 수용체 4 프로모터 단일 뉴클레오타이드 유전자 다형(-2027A>G, -1608T>C)에 대한 유전자형을 분석하였다. 혈청 Chitinase의 농도는 밀가루 분진에 노출된 제빵공에서 대조군보다 유의하게 높았다(P=0.026). 그러나 작업 관련 증상이나, 혈청 특이 IgE 유무에 따른 차이가 없었다. …
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TNF inhibitors for the prevention of Alzheimer’s disease
… diseases including tumour necrosis factor-alpha (TNFa), a proinflammatory cytokine which has been associated with an increased rate of neurodegeneration and risk of conversion from mild cognitive impairment (MCI) to AD dementia. This led to the development of a hypothesis which suggested that …
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Treating type 2 diabetes through insulin resistance
… selenium and chromium. The putative role of TNFa in insulin resistance was also investigated. Lipoic acid improved insulin-stimulated glucose uptake in normal and insulin resistance murine muscles, as well as cultured myocytes. Isoferulic acid, bradykinin and LMF also produced a transient …
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Basi molecolari della differente risposta delle cellule alpha e beta del pancreas di mammifero all apoptosi mediata da citochine: implicazioni patogenetiche nel Diabete Mellito
… pro-infiammatorie l IL-1b, l IFNg ed il TNFa rappresentano i principali effettori degli eventi descritti. E interessante notare come l'azione deleteria delle citochine sia specificatamente rivolta alle cellule beta pancreatiche, mentre le cellule alpha risultano più resistenti ai loro …
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