Aspects of structure-activity relationships and physiology of gastrin and related peptides

When, in 1973, I embarked upon this study, the hormone gastrin seemed a suitable hormone to study with regard to investigation of structure-activity relationships and physiology of a peptide hormone. Gastrin was best known at that stage as a linear peptide comprising 17 amino acids, which was stable at room temperature and was resistant to degradation by vigorous treatments such as boiling {Gregory and Tracy, 1964; Berson and Yalow, 1971; Yalow and Berson, 1972) and pH extremes (Piszkiewicz, 1974). Such a molecule could thus be studied at room temperature, using conventional biochemical techniques, without the need for any special precautions to preserve its integrity.

Grantor

Department of Medicine

Year dc:date.issued

1978

Author dc:creator

• Napier, Beverley Jean

Advisor dc:contributor.advisor

• Vinik, Aaron I

• Peptides
• Physiology
• Gastrins

Handle dc:identifier.uri

http://hdl.handle.net/11427/32048

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/32048