Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 2364 for “"Peptides"”.
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Novel Endogenous Antimicrobial Peptides
Antimicrobial peptides serve as a first line of defence against invading microorganisms and are an essential part of our fast innate immune system. They are ancient molecules found in all classes of life. Antimicrobial peptides rapidly kill a broad spectrum of microbes and are immunomodulatory, …
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AGEing Peptides: Synthesis and Analysis of Peptides Site-Specifically Modified by Advanced Glycation Endproducts
… biochemistry by providing access to synthetic peptides that can be site-specifically modified by particular AGEs. Five prominent lysyl AGEs, Nε-carboxymethyllysine (CML), Nε-carboxyethyllysine (CEL), pyrraline, glyoxal lysine dimer (GOLD), and methylglyoxal lysine dimer (MOLD), were selected as …
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Mass spectrometry of crosslinked peptides
… advancing the identification of crosslinked peptides by analysing their mass spectrometric fragmentation behaviour and leveraging the knowledge gained for the development of advanced acquisition methods. First, I investigate the influence of the employed fragmentation method and parameters on …
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Design of Collagen-Mimetic Peptides
… is significantly larger than other collagen-like peptides which are only 30-45 residues long.</p>
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Anticancer Potential of Soy Peptides
… the anticancer potential and mechanism of soy peptides have not been fully understood. The objective of this research was to evaluate the anticancer potential of soy peptides and to elucidate the role of lunasin on an established cancer cell line. The anticancer potential was determined by the …
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Long peptides for cysteine arylation
… acids). Here, we attempted to first discover peptides roughly 30 amino acids in length that promote a nucleophilic aromatic substitution reaction and then understand the features and properties that emerge. Using the 20 canonical amino acids, there are 20³⁰ different peptide sequences possible …
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Pro-Angiogenic Self-Assembling Peptides
Peptide amphiphiles (PAs), peptides that self-assemble into hydrogels with a nanofibrous network, are interesting biomaterials due to their biocompatibility and biodegradability. Self-assembling peptide-based materials include a wide range of peptide motifs that form one-dimensional nanostructures …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… a novel group of linear and cyclic amphiphilic peptides containing different sequences of arginine (R) and tryptophan (W) residues. The peptides included a class of cyclic peptides, [R3W3]2, [R3WRW]2, [RWW]4, [WRR]4, [RWRW3]2, and the corresponding linear peptides, (R3WRW)2, (RWW)4, (WRR)4, …
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Genome mining for natural product biosynthesis: Amino acids, nonribosomal peptides, and ribosomal peptides with posttranslational modifications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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ANTIMICROBIAL PEPTIDES FOR A SUSTAINABLE AGRICULTURE
L'agricoltura moderna si basa principalmente sull'utilizzo di pesticidi chimici per proteggere le colture da patogeni e parassiti. Tuttavia, l'uso massiccio di questi composti ha portato all'insorgenza di ceppi resistenti, all'inquinamento ambientale e al danno agli organismi non bersaglio. Per …
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Ribosomal Synthesis of N-methylated peptides
… libraries is valuable in screening for drug-like peptides suitable for therapeutic uses. Protein synthesis using recombinant elements (PURE) and Flexizyme were used in order to reassign specific codons to N-methyl amino acids. mRNA-dependent translation system enable us to make our desired …
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Folding and aggregation of amyloid peptides
… of the fibril-like dimers and trimers individual peptides are fully extended forming in- or out-of-register antiparallel β-sheets. A small amount of fibril-like trimers contained V-shaped peptides forming parallel β-sheets. The dimensions of extended and V-shaped oligomers correspond well to the …
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Single label fluorescent derivatization of peptides
… the attachment of a single fluorescent label to peptides through their N-terminus is described. The method employs fluorescein-5-isothiocyanate as the label of choice and a lower than normal derivatization buffer pH that discriminates against $\varepsilon$-amino derivatization in favor of …
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Targeting PfUCHL3 Using Chemically Constrained Peptides
… Y et al, 2011), 10 novel, non-natural, cyclic peptides were selected for against PfUCHL3. The peptides all display tight dissociation constants for PfUCHL3 in the low nanomolar range (6-35 nM) and 4 of the 10 peptides inhibit the activity of PfUCHL3 in cleaving its ubiquitin substrate *in …
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Isotope edited FT-IR of peptides
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… research objective is to discover anti-CD47 peptides via phage display biopanning that can block CD47/SIRPα interaction to facilitate the macrophage-mediated phagocytosis of tumor cells. These anti-CD47 peptides can be promising innate immune checkpoint inhibitors that can be combined with …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… II (Ang II), one of the biologically active peptides of the renin-angiotensin system, elicits many maladaptive effects on the cardiovascular system. Over the past two decades, numerous studies demonstrated that the other biologically active angiotensin peptide, angiotensin-(1-7) [Ang-(1-7)], …
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Archaeal signal peptides and cell surface structures
… binding proteins with extremely short signal peptides in S. solfataricus. In this thesis, in vitro comparisons of the signal peptide length requirements for the two different preflagellin peptidases, FlaK in M. voltae and PibD in S. solfataricus, are presented. While a signal peptide length …
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