β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor

Over-expression of β-arrestin 1 in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH receptor are required for β~arrestin dependent internalisation, chimeric receptors were created.

Grantor dc:publisher.institution

Department of Clinical Laboratory Sciences

Year dc:date.issued

2006

Author dc:creator

• Nkwayana, Nonhlanhla

Advisor dc:contributor.advisor

• Katz, Arieh

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3178

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3178