Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 180 for “"Internalisation"”.
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Internalisation of the type II gonadotropin-releasing hormone receptor of marmoset monkey
… investigated, therefore this thesis studies the internalisation pathway of the type ll GnRH receptor. As the C-terminal tail mediates rapid internalisation of many G protein-coupled receptors this research investigates the functional role of the C-terminal tail and intracellular loop in receptor …
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Antibody engineering to evaluate binding, internalisation, and intracellular routing of tumour-targeting fusion proteins
… substrates. To enhance antigen binding, internalisation, and therapeutic efficacy, a bivalent scFv fusion protein was created in tandem with the standard monovalent fusion protein. In vitro experiments using fluorophores and the cytotoxin, monomethyl auristatin F (AURIF), demonstrated …
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South African peace mission personnel and sexual misconduct against women in the Democratic Republic of Congo: A Constructivist exploration of Norm Internalisation
… lens to examine the mechanisms behind Norm Internalisation, and by analysing how this applies to South African personnel, this research identifies some of the reasons why South Africa’s apparent commitment to international norms about women does not always result in appropriate behaviour. …
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The Failed Internalisation of the European Convention on Human Rights in Russia: The Gap Between Values and Norms, and the Contested Meaning of Dignity
… a good complier with the ECHR. I argue that the internalisation of the ECHR in Russia was obstructed by the conceptual contestation of the Convention’s foundational values. In Russia and in the USSR, there was always a competing set of values through which the state interpreted its human rights …
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How leadership is shaping multinationals and the need for managers to have a global mindset approach : managerial cognition and the influence on the internalisation process of an emerging market firm
The world in which business is conducted has become more interconnected than ever, with institutions being intertwined in the manufacturing and delivery of products and services on a global scale. Organisations are required to continuously adapt and realign their strategic intent to a global …
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Influence of Peptide Allosteric Modulators on Agonist Bias at Class B1 G Protein-Coupled Receptors
… added variation in receptor desensitisation and internalisation, with intracellular signalling and β-arrestin-mediated pathways adding spatial and temporal complexity. How this crosstalk regulates intracellular signalling was investigated at the Glucagon-Like Peptide-1 Receptor (GLP1R), a Class …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
… in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH receptor are required for β~arrestin dependent internalisation, chimeric receptors were created.
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Switching the human-power back on: domesticating human-power to practice energy saving behaviour
… to further study; and developing a ‘HPP Internalisation Model’ which hypothesised the suggestive design strategy for prolonging the HPP use. The hypotheoretical state of ‘HPP Internalisation Model’ was empirically iterated and final recommendations was integrated into a research artefact. …
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
… induces signalling (within seconds) but also the internalisation of the receptor by clathrin-mediated endocytosis (within minutes) to switch off signalling. Previous data from our lab for the GPCR Sphingosine-1-Phosphate Receptor 1 (S1PR1) suggested a new role of P-Rex in GPCR trafficking. P-Rex …
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Molecular Analysis of Hepatitis C Virus Envelope Glycoprotein E2 Binding and Entry
… is competent both for targeted binding and for internalisation into hepatoma cells. Rates of E2-Fc internalisation differ between cell types, being dependent on the density of the CD81 receptors displayed on the cell surface, to an extent. Internalised E2-immunoadhesin localises with endocytosis …
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Investigating the molecular pharmacology of class A and B G protein-coupled receptors
… receptor activity-modifying proteins (RAMPs), or internalisation, whereby distinct responses may be propagated by intracellular GPCR populations. Hence, the signalling repertoire subsequent to receptor activation is extremely complex, varying between individual GPCRs and the biological systems in …
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Synthesis, Characterisation and Biological Activity of Silicon Nanoparticles Functionalised by Anticancer Compounds
… Confocal microscopy images demonstrate SiNP internalisation and flow cytometry data confirms receptor-mediated targeting in cancer cells. Isothiocyanates (ITCs) can prevent the onset of carcinogenesis and act as chemopreventive compounds. ITC-functionalised SiNPs were synthesised using two …
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The role of idealised image features in determining post-exposure body image and social comparisons
… at post-exposure. In addition, thin ideal internalisation and restraint were examined as possible moderators. Studies 1, 2a, 2b, and 3 indicated that idealised image relevance and salience had little differential impact on post-exposure body image. That is, exposure to thin idealised …
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The role of intracellular and extracellular cysteines in regulating human proteinase-activated receptor-2 (hPAR2) function
… to assess the rate, and extent of receptor internalisation following agonist challenge. hPAR2C361A displayed faster internalisation kinetics following trypsin activation, compared to wt-hPAR2, whilst SLIGKV-NH2 had negligible effect on internalisation for either receptor.This study has …
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Investigating the effects of extracellular biomolecules on Aß1-42 oligomer uptake and trafficking by microglia cells
… toxic species. This thesis explores the internalisation of SO by a microglia cell line (EOC 13.31) and provides new in- sights into the modulation of this process by naturally occuring extracellular biomolecules, namely the chaperone clusterin (Clu) and the antimicrobial enzyme lysozyme, …
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The role of the microglial P2Y₆ receptor in ageing, development, and tauopathy
… increase in synapses was coupled with reduced internalisation of synaptic material within CD68+ lysosomes in Iba1+ microglia in P30 *P2ry6⁻´⁻* mice. This indicates that P2Y₆R-dependent phagocytosis of synapses contributes to synaptic loss late in development. *In vitro*, P2Y₆R deficiency …
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An investigation of the assumptions of self-handicapping : youth responses to evaluative threat in the physical domain
… but if used continually, pathological internalisation is a possibility. This thesis investigated some of the assumptions held for self-handicapping by exploring how a stratified random sample of young people aged between 10 and 16, self-handicapped when faced with an evaluative threat …
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Children and teacher's perceptions of ADHD and medication
… of the data revealed a grounded theory of internalisation of the ADHD label for children, and difference for teachers. Children were found to experience ADHD emotionally, in on/off conditions, as a medical disorder, with external locus of control and as part of their self/identity. …
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Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?.
… role of the OPRM1 A118G variation for receptor internalisation following methadone treatment was investigated. A significant association was identified between high post-mortem methadone concentrations and G561T and A785G (CYP2B6*6) variations reflecting poor methadone metabolism. Furthermore, …
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