Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer

Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2008

Author dc:creator

• Li, Dong-Ping

Advisors dc:contributor.advisor

• Parker, Iqbal
• Dandara, Collet

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3137

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3137