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Showing 1 to 20 of 87 for “"Genetic polymorphisms."”.

  1. The Use of Genetic Polymorphisms and Discriminant Analysis in Evaluating Genetic Polymorphisms as a Predictor of Population

    Howell, Bruce F.University of North Texas2002

    … quantitative predictor variables. Data bases of genetic polymorphisms are currently available that group such polymorphisms by ethnic origin or nationality. Such information could be useful to entities that base financial determinations upon predictions of disease or to medical researchers who …

    unt Repository record

  2. Genetic Polymorphisms of Interleukin-6 in Systemic Lupus Erythematosus

    전, 자영2011

    … inflammatory and immune responses, and IL-6 gene polymorphisms are known to play a part in chronic inflammatory and autoimmune disorders. We have identified single nucleotide polymorphisms (SNPs) in the IL-6 gene, determined their frequency in Korean populations, and elucidated their difference …

    ajou Repository record

  3. Genetic polymorphisms in breast cancer in relation to risk and prognosis

    Bågeman, ErikaDepartment of Oncology, Clinical Sciences, Lund University2008

    … cancer is modified by environment, lifestyle, genetics and a combination of these factors. In this thesis work the combination of lifestyle and genetic polymorphisms on tumor characteristics and early recurrence have been studied. Absence of the common 19 CA repeat allele in the insulin-like …

    lund Repository record

  4. The influence of genetic polymorphisms and natural health products on drug metabolism

    Chauhan, BobbyUniversity of Ottawa (Canada)2013

    … specifically examined the influence of polymorphisms within the ABCB1 gene on P-gp efflux activity and expression. Additionally, the role of natural health products (NHPs) on the activity of both P-gp and members of the CYP3A subfamily was also studied. Findings from this study suggest …

    ottawa-retro Repository record

  5. Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk

    Pikovsky, Irena Y.

    … However, prior work involving three polymorphisms (COMT Val158Met, MAOA-LPR, and 5-HTTLPR) has yielded well publicized but inconsistently replicated associations with mental health. Part of this inconsistency may be due to the limited exploration of mechanistic explanations for how …

    denver Repository record

  6. Genetic polymorphisms and organophosphate neurotoxicity amongst emerging farmers in the Western Cape

    Glass, TracyCentre for Infectious Disease Epidemiology and Research (CIDER)2016

    … neurotoxic effects which may be modulated by genetic polymorphisms of xenobiotic metabolising enzymes (XMEs). No previous study investigated XME modulation of neurotoxicity outcomes. OBJECTIVES: To investigate whether XMEs polymorphisms modulate OP neurotoxicity among emerging farmers. …

    cape-town Repository record

  7. Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia

    Wei, Qi2001

    … protocols have incorporated somatic but not host genetic features in the treatment regimens. The current study examined 12 genetic polymorphisms affecting the pharmacodynamics of antileukemic drugs in an attempt to identify biologic markers related to the risk of disease relapse.</p> <p>In the …

    denver Repository record

  8. Association and functional studies of genetic polymorphisms of MFGE8 gene in systemic lupus erythematosus

    우, 지민2016

    … patients. In this study, we determine whether genetic variation of MFGE8 gene and serum protein concentration are associated with SLE. MATERIALS AND METHODS: We collected the blood samples from SLE patitents (n = 280) and normal controls (NC, n = 260) at the rheumatology clinic of Ajou …

    ajou Repository record

  9. Significant Association of ADORA3 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population

    남, 은주2011

    … the Korean population. The functional effects of genetic polymorphisms in ADORA3 were analyzed by luciferase reporter assay, electrophoretic mobility shift assay (EMSA), and real-time PCR for the mRNA expression in PBMC of AIU patients. RESULTS: The haplotype [T-1050C-564] frequency of ADORA3 gene …

    ajou Repository record

  10. Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa

    Matejcic, MarcoDivision of Medical Biochemistry2013

    … disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research group have reported that genetic polymorphism of …

    cape-town Repository record

  11. Effects of host genetic polymorphisms on the occurrence of schistosomiasis and chlamydia in Limpopo Province

    Mafokwane, Tshepo Malesela2016

    MSc (Microbiology)

    venda Repository record

  12. Investigating the role of host genetic polymorphisms in periodontitis susceptibility in a Western Cape population

    Kabbashi, Salma Mohamed KhalifaUniversity of the Western Cape2024

    … pathogenesis involves studying both host genetics and microbial factors. Research shows that genetic susceptibility varies by ethnicity, with disparities in periodontitis prevalence across populations. In South Africa, limited dental access and diverse ethnicities add complexity to …

    western-cape Repository record

  13. Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population

    손, 진경2011

    … B4. The aim of this study is to elucidate the genetic contribution of the IL-18 gene on the phathogenesis of AIU. MATERIALS AND METHODS: To perform genetic association study of IL-18 gene polymorphism with AIU, 247 patients with aspirin-intolerant urticaria (AIU) and 196 normal healthy …

    ajou Repository record

  14. Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer

    Li, Dong-PingDivision of Medical Biochemistry2008

    … of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) …

    cape-town Repository record

  15. Association between Genetic Polymorphisms of Enzymes Involving Mevalonate Pathway(GGPS1 and FDPS) and Bone Mineral Density Response to Bisphosphonate Treatment

    김, 연경2011

    Geranylgeranyl diphosphate synthase1(GGPS1)과 farnesyl diphosphate synthase(FDPS)는 골다공증 치료제인 질소 함유 비스포스포네이트가 억제하는 표적효소로, 환자마다 비스포스포네이트에 대한 반응이 달리 나타나는 이유는 이 표적효소들의 유전자 다형성에서 기인하는 부분이 있을 것으로 생각된다. 본 연구의 목적은 GGPS1, FDPS 유전자에서 한국인 고유의 유전자 다형성을 찾고, 이에 따라 비스포스포네이트 투여에 대한 반응에 차이가 있는지를 평가하는 것이다. 골다공증 외에 …

    ajou Repository record

  16. A genetic epidemiological study of prevalence and association of genetic polymorphisms in asthma related phenotypes among children in Durban, Kwazulu-Natal

    Makamure, Michelle2018

    Submitted in fulfillment of the requirements for the degree of Master of Technology: Health Sciences, Durban University of Technology, Durban, South Africa, 2013.

    dut Repository record

  17. Individual Differences in the Dopaminergic Reward System: The Effect of Genetic Risk on Neural Reward Sensitivity and Risky Choice

    Soder, Heather E.Digital Commons @ University of South Florida2015

    … system, and this system is in part modulated by genetic polymorphisms that are associated with dopamine transmission. The current study tested if genetic polymorphisms that are associated with enhanced dopamine neurotransmission will be more neurally reward sensitive, score higher on …

    usf Repository record

  18. Prevalence and frequency spectra of single nucleotide polymorphisms at exon-intron junctions of human genes

    Lupindo, BukiweDepartment of Molecular and Cell Biology2008

    … to DNA sequence variations in human populations. Genetic variations that affect splicing have been shown to cause variation in splicing patterns and potentially are an important source of phenotypic variability among humans. Furthermore, variation in disease susceptibility and manifestation …

    cape-town Repository record

  19. Biomonitoraggio umano: effetti sub-clinici da Piombo e Cadmio sull’accrescimento

    MILIA, NICOLAUniversità degli Studi di Cagliari2015

    … individual susceptibility to absorption by using genetic polymorphisms involved in Pb and Cd metabolisms,. Methods: The total sample consists of 144 children of both sexes (11-14 years), living in different municipalities of Sardinia (Italy) of Sulcis-Iglesiente area, Sant’Antioco and Iglesias, …

    cagliari Repository record

  20. Population-based prediction of atrial fibrillation

    Smith, GustavLund University2012

    … to AF has recently been established and genetic polymorphisms associated with AF risk. The aim of this thesis was therefore to evaluate the ability of genetic polymorphisms, conventional cardiovascular risk factors and blood biomarkers reflecting diverse pathophysiological pathways to …

    lund Repository record

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