Spatial and temporal regulation of IL4Rα expression

In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005).

Grantor dc:publisher.institution

Division of Immunology

Year dc:date.issued

2008

Author dc:creator

• Smith, Elizabeth M

Advisors dc:contributor.advisor

• Brombacher, Frank
• Horsnell, William

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3117

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3117