Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"VAV"”.
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
… Rho-family GTP exchange factor (GEF) Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody dependent …
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The role of ACK in regulating the Vav family proteins
… one of which was a small G protein regulator Vav3, the least-studied member of Vav-family proteins. The first part of this project characterised the interactions between ACK and Vav-family proteins in human cells. ACK was shown not only to bind to Vav3, but also to Vav1 and Vav2. From …
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Dynamic performance of control loops and their interactions in a VAV HVAC system
… occupant comfort. During the last 10 years, VAV-HVAC systems are widely used in commercial buildings because they can reduce energy use significantly and provide good temperature control of the conditioned spaces compared to CV-HVAC systems. However, the controls for VAV systems are somewhat …
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Velocity profile in confined elliptic fractures
… profile is highly non-uniform, and the use of Vav creates an error as Vmax >> Vav. The variation in hydraulic diameter associated with an elliptic cross-section of a confined fracture as given by the Perkins/Kern mode16 is responsible for the large difference between Vmax and Vav. It is shown …
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Dynamic modeling and global optimal operation of multizone variable air volume HVAC systems
… models of a multizone variable air volume (VAV) system have been developed using (i) bottom-up and (ii) top-down approaches. The models take account of the dynamic interactions between building shell, VAV system components and control systems. The models describe the dynamics of fan, air …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… One of this study, I identify a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and …
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Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… TRE -driven transgenes when combined with Vav-tTA , because mastocytosis was developed in Vav-tTA ; TRE-NRAS G12V transgenic mice without detectable other diseases. We assayed Vav-tTA -driven luciferase expression in hematopoietic cells including bone marrow-derived mast cells (BMMC) and …
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Kostnaðarsamanburður á loftræsikerfum með stöðugt og breytilegt loftmagn
… Loftræsikerfi með breytilegt loftmagn (VAV), hannað árið 2012, var endurhannað sem loftræsikerfi með stöðugu loftmagni (CAV). Bæði kerfi voru magntekin og ný verð fengin í alla íhluti kerfa til að samanburður yrði sem nákvæmastur. Farið var yfir kosti og galla VAV og CAV kerfa og …
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CEACAM3: ein neuartiger phagozytischer Rezeptor der angeborenen Immunantwort zur Erkennung human-spezifischer Pathogene
… der kleinen GTPase Rac identifiziert werden. Das Vav Protein fungiert dabei als GEF für die kleine GTPase Rac. Eine dominant negative Version von Vav oder eine spezifische Vav-siRNA inhibieren die CEACAM3-vermittelte Aufnahme von OpaCEA-Gonokokken bzw. die GTP-Beladung von Rac. Interessanterweise …
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Analysis and characterization of ancillary service demand response strategies for variable air volume HVAC systems
… to identify real-world operational qualities of VAV systems to be considered by building researchers and building practitioners. This includes the relative magnitude of building power loads, the direct and indirect relationships between environmental conditions and HVAC power consumption, the …
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Spatial and temporal regulation of IL4Rα expression
… the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005).
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Reading With the Masoretes: The Exegetical Utility of Masoretic Accent Patterns
… in the presence of the contrast structures vav + X + verb, and vav + לא + verb (e.g., Judg 1:27; 2:17; 10:13). The examination of these patterns forms the heart of the dissertation. At least three practical implications for exegesis emerge from this study: (1) confirmation of clause …
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Energy Performance and Economic Evaluations of the Geothermal Heat Pump System used in the KnowledgeWorks I and II Buildings, Blacksburg, Virginia
… to the conventional package variable air volume (VAV) with hot water coil heating and air-source heat pump systems using computer simulation and statistical models. The quantitative methods of building energy performance and life-cycle cost analyses are applied to evaluate the results of …
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The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling
… the 95kDa guanosine nucleotide exchange factor, Vav, and the 76kDa adaptor protein Slp76. This proceeds in a similar manner to that observed at the TCR. Furthermore, the absence of either protein impairs IFNAR-induced ERK MAPK signalling. The similarities between TCR and IFNAR signalling led to …
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Building load control and optimization
… in a single building. A simple three-zone VAV system model is built in EnergyPlus (E+). The cost function structures and the potential difficulties associated with simulation-based optimization are discussed. Discontinuity and nonlinearity are of major concern. Two optimization algorithms …
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Evaluating the performance of passive chilled beams with respect to energy efficiency and thermal comfort
… volume system. However, the variable air volume (VAV) system consumed 21% less energy compared to the passive chilled beam system during the field measurements. This is mostly because of the current configuration of the passive chilled beam system which represents the worst case scenario in terms …
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
… and normal resistance to Listeria infection, Vav-icre+Ifngr1f/f mice lacking IFNg responsiveness selectively in hematopoietic cells exhibited highly increased susceptibility to Listeria infection comparable to that of Ifngr1-/- mice. In contrast, Itgax-cre+ Ifngr1f/f mice lacking IFNg …
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The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
… assays (ELISA). Additionally, the Tet2flox/flox Vav-iCre mouse model was used to investigate the effects of Tet2-deficiency on neutrophils. Motility and phagocytosis were assessed through a Staphylococcus aureus phagocytosis assay. RNA sequencing (RNA-seq) was performed to analyze transcriptomic …
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… Excision of Arap3 in hematopoietic cells using Vav-Cre does not alter the ability of ARAP3-deficient HSCs to provide multi-lineage reconstitution and to undergo self-renewal, suggesting ARAP3 does not play a cell-autonomous role in HSCs. Deletion of Arap3 in osteoblasts and mesenchymal stromal …
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Improving the use of commercial building HVAC systems for electric grid ancillary services
… techniques. First, a model of a representative VAV system is built using Modelica and simulated to characterize the system's performance while providing reserve and regulation ancillary services. It is found that reserves are provided most effectively when airflow is reduced through the terminal …
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