The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation

Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due to poor egg excretion and dysregulated granuloma formation. This resulted in increased mortality. To determine the role of AAMФ in granuloma we aimed to describe S.mansoni egg induced granuloma formation in the presence and absence of AAMФ using LysMcreIL-4Rα-/lox mice.

Grantor dc:publisher.institution

Division of Immunology

Year dc:date.issued

2008

Author dc:creator

• Marillier, Reece Gerrad

Advisor dc:contributor.advisor

• Brombacher, Frank

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3113

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3113