Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 287 for “"IL-4"”.
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Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha
… and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
… is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to …
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The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis
… associated with protection, many individuals still have progressive active TB. Whether a Th2-like immune response (IL-4; IL-4δ2; IL-9) can subvert protective host immunity requires clarification.
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Characterisation of novel T cell specific IL-4 receptor-alpha knockout mice : investigating the role of T cell responses to IL-4 in Leishmania major and Nippostrongylus brasilliensis infections
Includes bibliographical references (leaves 76-86).
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
… In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated progenitor cells. One particular enzyme activated by both IGF-I and IL-4 is phosphatidylinositol 3$\sp\prime$-kinase, a lipid kinase which phosphorylates …
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The role of IL-4 receptor alpha in chronic allergic airway disease (AAD)
Includes abstract.
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Die Rolle von IL-4 und IL-13 in Maus-Modellen für allergische Erkrankungen
IL-4 und IL-13 sind wichtige Faktoren bei der Entwicklung allergischer Erkrankungen. In dieser Arbeit wird die Rolle von IL-4 und IL-13 in einem Maus-Modell für allergisches Asthma während der allergischen Sensibilisierung und in einer etablierten asthmatischen Erkrankung untersucht. Weiterhin wird …
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Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis
… limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the superficial layer of the mucosa. The Th2 cytokines interleukin (IL)-4 and IL-13 are associated with the onset of oxazolone colitis and both signal through a common IL-4 receptor-alpha chain (IL-4R +-). Neutralizing …
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The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation
… the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due …
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Die Bedeutung der Expression des IL-4 Rezeptors für die Prognosestellung beim lokal begrenzten Nierenzellkarzinom
… zwischen dem Ausmaß der Expression von IL-4 Rezeptoren und der Prognose der Erkrankung gibt. 198 formalinfixierte und in Paraffin eingebettete Präparate von Nierenzellkarzinomen wurden immunhistochemisch aufgearbeitet und unter dem Lichtmikroskop ausgewertet. Mittels statistischer Tests …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… show efficacy in AD patients. However, targeting IL-4/IL-13 signalling axis with dupilumab show efficacy in AD. We investigated the importance of interleukin 4 receptor alpha (IL- 4Rα) signalling specifically on B and T cells to understand the requirement of this signalling axis in epicutaneous …
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Computational modeling of the IL-4 pathway to understand principles of systemic redox regulation in cell signaling
… and disease, years of clinical studies have failed to show clear benefits of antioxidant therapy. It is now recognized that ROS such as hydrogen peroxide can act as signaling molecules and are required for physiological functioning of a number of signaling pathways. Therefore, a mechanistic …
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Charakterisierung von IL-4 Knockout-Mäusen und ihrer Zytokin- und Opioidrezeptor-Expression im peripheren und zentralen Nervensystem
… des antiinflammatorischen Zytokins Interleukin(IL)-4 am Tiermodell einer experimentellen Mononeuropathie (engl. chronic constriction injury, CCI) untersucht. Zentrale Fragestellung der Studie war, ob IL-4 knockout(ko)-Mäuse im Vergleich zu Wildtyp(wt)-Mäusen mit einem gesteigerten …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… hypothesis that interleukin-4 receptor alpha (IL-4Rα) signalling on T regulatory cells (T reg) play a role in the stability of T reg cells. Loss of IL-4Rα signalling on T reg cells may shift the immune balance from a Foxp3+ T reg to a Th1 effector function essential for Th1 disease outcome. …
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IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis
… (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to current antimicrobials. Non-coding RNAs are emerging as important regulators of …
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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection
In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor subunit, the IL-4 receptor alpha chain (IL-4α ). While …
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Generation of mice expressing a constitutively active stat6: a model for the analysis of IL-4 signaling and tumor progression
… scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… primary and secondary infections with N. brasiliensis. Our findings demonstrate that CD28 is required for initiation of protective Th2 immunity against primary infection with N. brasiliensis. Furthermore, the absence of CD28 impairs development of memory CD4⁺ T cell responses resulting in …
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Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4
… factors associated with its pathogenesis are still not completely understood. Cysteinyl leukotrienes (CysLTs) play important roles in eosinophilic airway inflammation of AIA via CysLTR1-mediated mechanism. Leukotriene modifier MK-571, a selective CysLTR1 antagonist, is widely used in the …
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The role of IL-4 and IL-13 in pulmonary tuberculosis using gene-deficient mice and protective efficacy of the purine-deficient auxotroph of Mycobacterium tuberculosis
Absence of the TH2 inducing cytokine IL-4 has been shown not to increase the TH1 response and resistance to mycobacterial infection. This study asked whether the combined absence of IL-4 and IL3, as compared to IL-4 deficiency only, would increase resistance to an aerogenic Mycobacterium …
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