Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort

To date, surgery is the mainstay treatment for HNPCC. Adjuvant chemotherapy and radiotherapy are often used to reduce systemic and locoregional recurrence, respectively, after curative surgical resection. The main chemotherapeutic agent is 5-Fluoroucacil (5-FU). Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with MMR-proficient and MMR-deficient tomours were detected.

Grantor dc:publisher.institution

Division of Human Genetics

Year dc:date.issued

2009

Author dc:creator

• Meyer, Jacqueline

Advisor dc:contributor.advisor

• Ramesar, Raj

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3099

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3099