Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 125 for “"MMR"”.
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MSH2 nuclear localization and MMR apoptotic response to DNA damage.
<p>Mismatch repair (MMR) proteins have previously been implicated to play a role in cellular apoptotic response to chemotherapeutics. However, what has not been established is how these proteins participate in both repair events and apoptosis. We are here investigating if cellular …
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Parental perceptions of childhood immunisation in the context of the MMR controversy
… examines how parents have conceptualised the MMR controversy and offers an assessment of parents’ perceptions of vaccine-preventable diseases and childhood immunisation. Methods-Eighteen focus groups were conducted in central Scotland between November 2002 and March 2003, with a diverse range …
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Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
<p>Mismatch Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including <em>MLH1</em>, <em>MSH2</em>, <em>MSH6</em>, and <em>PMS2. </em>These genes play a critical role in repairing errors that occur in base pairing by …
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Examining measles, mumps, and rubella (MMR) immunization uptake in Saskatoon: Can neighbourhood characteristics predict coverage rates?
… uptake of the Measles, Mumps, and Rubella (MMR) vaccine. Once neighbourhood coverage rates were calculated, the project centred on using quantitative neighbourhood level data to determine if the neighbourhood variables of interest could significantly contribute to the explanation in …
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Examining the Relationship between Race, Ethnicity, and Sociodemographic Factors and Coverage of Three Vaccines: COVID-19, MMR, and HPV
… coverage for, 1) measles, mumps, and rubella (MMR) and 2) HPV, and explored the reasons behind COVID-19 vaccine hesitancy among Black women. In Manuscript 1, I used qualitative methods to understand COVID-19 vaccine decision-making among a diverse set of Black women in the Minneapolis-Saint …
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The Crosstalk Between DNA Mismatch Repair and Replication
… fidelity relies on DNA mismatch repair (MMR) and the proofreading nuclease activity of DNA polymerases. Normally, biosynthetic errors can be removed by the polymerase's proofreading nuclease activity upon their incorporation, and those errors that have escaped the proofreading nuclease …
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Quantitative genetics and metabolomics of aerobic metabolism
… of variation in maximal aerobic metabolic rate (MMR) are important for understanding exercise physiology and the evolution of aerobic performance, but they still are not well understood. To this end, I studied three aspects of MMR. First, I estimated the genetic variances and covariances of MMR …
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Mismatch Repair Protein-Dependent Cytotoxic Signaling In Cells Treated With The Cancer Chemotherapeutic Cisplatin
Mismatch repair (MMR) proteins participate in cytotoxicity induced by specific genotoxic agents, including cisplatin (CDDP, cis-diamminedichloroplatinum(II)), a cancer chemotherapeutic drug utilized clinically to treat a variety of malignancies. The MMR protein complex MutSα (consisting of the MSH2 …
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Mismatch Repair Deficient Cancer Diagnostic Aspects in Colorectal Cancer and the Role of Urological Cancer in Lynch Syndrome
Mismatch repair (MMR) deficiency is carcinogenic and can either have somatic/sporadic causes (i.e. epigenetic silencing or somatic inactivation) or hereditary causes (Lynch syndrome due to a germline mutation in one of the MMR genes ¬- MLH1, MSH2, MSH6, PMS2). The identification of MMR defective …
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An Efficient Platform for Large-Scale MapReduce Processing
In this thesis we proposed and implemented the MMR, a new and open-source MapRe- duce model with MPI for parallel and distributed programing. MMR combines Pthreads, MPI and the Google's MapReduce processing model to support multi-threaded as well as dis- tributed parallelism. Experiments show that …
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Control of Vibration Systems with Mechanical Motion Rectifier and their Applications to Vehicle Suspension and Ocean Energy Harvester
… of a novel mechanical motion rectifier (MMR) gearbox that uses mechanical one-way clutches in both systems. The flow is from the control for common system to the control design for a specifically designed system. In the thesis, active (model predictive control: MPC), semi-active (Skyhook, …
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… during DNA replication. The Mismatch repair (MMR) pathway rectifies base mismatches. However, MMR is unable to correct these S6-MeG:T or O6-MeG:T mispairs. In fact, upon recognition of the lesions, MMR initiates a futile repair cycle resulting in apoptosis. Thus, MMR is required for the …
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Examining the effects of mid ocean ridge topography on 3D marine magnetometric resistivity model responses
… in the crust. The magnetometric resistivity (MMR) technique is a galvanic method which uses a bipole current source with a magnetometer receiver. The resistivity of the subsurface can be estimated from the magnetic field read in MMR. In order to analyze and invert MMR data taken near Mid Ocean …
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Examining the effects of mid ocean ridge topography on 3D marine magnetometric resistivity model responses
… in the crust. The magnetometric resistivity (MMR) technique is a galvanic method which uses a bipole current source with a magnetometer receiver. The resistivity of the subsurface can be estimated from the magnetic field read in MMR. In order to analyze and invert MMR data taken near Mid Ocean …
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Pharmacogenomic profiling and clarification of the role of the mismatch repair genes in response to the chemotherapeutic agent 5-Fluorouracil in a South African colorectal cancer cohort
… Studies have attempted to elucidate whether the MMR status of a colorectal cancer (CRC) cohort will define a response to 5-FU therapy. However, no difference in long term response or survival after 5-FU treatment between patients with MMR-proficient and MMR-deficient tomours were detected.
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Genetic Counselor Utilization and Interpretation of Somatic Tumor Testing In Evaluation For Lynch Syndrome
… with pathogenic variants in the mismatch repair (MMR) genes (<em>MLH1</em>, <em>MSH2/EPCAM</em>, <em>MSH6</em>, <em>PMS2</em>) are diagnosed with LS and subsequently recommended to proceed with high risk screening protocols to increase prevention and early detection of LS-related cancers. Various …
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Shall we dance? : investigating protein interactions implicated in Escherichia coli postreplicative mismatch repair using a bacterial two hybrid system
… are integral elements of dam -directed repair (MMR), a mismatch recognition system involved in rectifying DNA replication errors. Moreover, MutS and MutL have been implicated in the effective endonucleolytic functioning of Vsr, primary player of very short patch (VSP) repair. This study made use …
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Identifying Children with Constitutional Mismatch Repair Deficiency (CMMR-D) Syndrome in the Expanding Lynch Syndrome population in Cape Town
… Constitutional Mismatch Repair Deficiency (CMMR-D) syndrome is a rare tumour predisposition and polyposis syndrome that presents in childhood. It is caused by mutations in mismatch repair (MMR) genes that result in a tumour spectrum including colorectal cancers, high-grade gliomas, …
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Student engagement and perceptions of quality learning in Higher Education in Angola and in other international contexts (Cuba, Portugal, and the United Kingdom): a convergent parallel MMR approach
… a convergent parallel mixed-methods research (MMR) approach. Data was collected through surveys (n=1010), individual interviews and focus group discussions (n=43), with the participation of students reading for the professional degree programmes of Law, Nursing, Accounting, Psychology, and …
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Studies of DNA repair and mutagenesis in Escherichia coli and Bacillus subtilis
… forty genes involved in repair. Mismatch repair (MMR) is a system by which the cell is able to avoid mutations by correcting DNA replication errors. Working with living Bacillus subtilis cells, the studies described here have found that MutS and MutL, the key proteins of MMR, form discrete foci in …
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