Gastric remnant carcinoma : histochemical and immunohistochemical profile

Gastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers. Partial gastrectomy for peptic ulcer is thought to be a risk factor for GRC. Pancreato-duodenal and bile reflux may play an important part in the aetiology of GRC. Primary gastric carcinoma (pGC) is a gastric cancer that arises in un-operated stomach and chronic gastritis is a well-known risk factor. Consequently there appear to be differences in the aetiology of GRC and PGC. According to many studies, surgical treatment of early GRC (Stage I or II) resulted in the same or better prognosis with similar stage PGC. However if diagnosed late, GRC has a worse prognosis than PGC at the same stage. In this study haematoxylin and eosin, alcian blue pH 2.5, periodic acid Schiff, high iron diamine and Giemsa stains as well as immunohistochemical methods (eight antibodies against MUCI to MUC6) were used to determine the type of mucin and the pattern of staining in twenty cases of GRC and twenty PGC (ten cases of intestinal type PGC, ten diffuse type PGC) and ten normal gastric mucosal biopsies. The aim of the study was to describe the morphology of GRC and the adjacent gastric mucosa, as well as to determine the histochemical and immunohistochemical mucin profile of GRC and to compare this with that of PGC and normal mucosa.

Grantor dc:publisher.institution

Division of Anatomical Pathology

Year dc:date.issued

2004

Author dc:creator

• Elazzabi, Tawfik

Advisor dc:contributor.advisor

• Mall, Anwar S

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/3076

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/3076