Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"PGC"”.
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Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
… coactivator PPARgamma coactivator 1alpha (PGC-1α) is a regulator of mitochondrial biogenesis and function and is decreased in the striatum of patients with Huntington’s Disease (HD). HD is an autosomal dominant neurological disorder caused by a polyglutamine repeat in the huntingtin protein …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function …
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Mechanistic Control of The Coldinduced Augmentation of The Transcriptional Co-Activator PGC-1α
… Despite these recent advances showing PGC-1α, the ‘master regulator’ of mitochondrial biogenesis, being augmented in its post-exercise response by cold water immersion, the precise controlling mechanisms remain to be determined. However, it has been suggested that local cooling effects …
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AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
… muscles undergoing atrophy have decreased [ATP], PGC-1[alpha] expression, and mitochondrial content. This combination of findings is unexpected because decreased [ATP] is often associated with greater [AMP] and subsequent activation of AMPK, a known inducer of PGC-1[alpha] activity and …
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Mechanisms of ventricular arrhythmogenesis in the age dependent Pgc-1β -/- model of mitochondrial dysfunction.
… needed to dissect them. In this study, we use Pgc-1β-/- mice as a murine model of mitochondrial dysfunction, to further investigate the link between mitochondrial and energetic insufficiency and arrhythmias. The study uses electrocardiographic data to characterise the phenotype at the whole …
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Using gravity to help us understand the AMPK-PGC-1α axis in skeletal muscle from healthy young males
… gamma coactivator 1-alpha (PGC-1α). Generally, the harder someone exercises (i.e. higher exercise intensities), the more PGC-1α increases. There are also several proteins that ‘turn on’ or activate PGC-1α, and these too increase as exercise intensity goes up. This means …
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Investigating the functions of PGC-1 isoforms in retinal pigment epithelia metabolism and their implications on age-related macular degeneration
… damage. The transcriptional co-activators, PGC-1α and PGC-1β, are important regulators of mitochondrial biogenesis and anti-oxidant capacity. Our group has previously shown that the PGC-1α protein promotes RPE oxidative metabolism and that overexpression of the PGC-1α gene protects cells …
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Atrial arrhythmogenesis in a murine model of mitochondrial insufficiency
… receptor γ coactivator-1 β (Pgc-1β-/-). Pgc-1β regulates mitochondrial biogenesis and function, and unlike other murine models of mitochondrial dysfunction Pgc-1β-/- mice have a mild cardiac phenotype, devoid of confounding contractile dysfunction. All experiments were …
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Psychiatric genetic counselling: current landscape and opinions of psychiatric healthcare professionals in public hospitals in Cape Town, South Africa
… are common, and psychiatric genetic counselling (PGC) aims to help people understand their, or a family member's, mental illness better, as well as help them understand the factors that can contribute to the development of a mental illness. However, PGC services are not implemented routinely …
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Psychiatric genetic counselling: current landscape and opinions of psychiatric healthcare professionals in public hospitals in Cape Town, South Africa
… are common, and psychiatric genetic counselling (PGC) aims to help people understand their, or a family member's, mental illness better, as well as help them understand the factors that can contribute to the development of a mental illness. However, PGC services are not implemented routinely …
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Gastric remnant carcinoma : histochemical and immunohistochemical profile
… the aetiology of GRC. Primary gastric carcinoma (pGC) is a gastric cancer that arises in un-operated stomach and chronic gastritis is a well-known risk factor. Consequently there appear to be differences in the aetiology of GRC and PGC. According to many studies, surgical treatment of early GRC …
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Genesis of the human germline
… specification of human primordial germ cells (PGCs) and the mechanism regulating the transient gain and loss of competence for germ cell fate. Specification of PGCs in humans occurs during weeks 2 to 3 in gastrulating embryos, which eventually develop into sperm and ova, generate totipotency at …
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Modeling the combined environmental effects on net land carbon flux in the present and future scenarios
… for the 2090s under SSP2-45 and SSP5-85 are 0.75 PgC/yr and 3.47 PgC/yr, respectively from the value of 0.24 PgC/yr for the 2010s. The atmospheric CO2 + N deposition effect contributes to the net sink of CO2 for the present decade (3.8 PgC/yr) and the last decade of the future scenarios (SSP2-45: …
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FFA membership growth compared to a changing and growing student population
… student population (percentage growth change, PGC) by state and region from 1990 to 2014 using data provided by the National FFA Organization and the National Center for Education Statistics (NCES). Using Ragin’s (1987) method of Qualitative Comparative Analysis (QCA), student population growth …
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Exploring the application of psychiatric genetic counselling within the UK.
… psychiatry. Psychiatric genetic counselling (PGC), which may address how our knowledge from genetic studies is delivered to patients, is likely to become more routinely available as our aetiological understanding of psychiatric illness increases. The present study explores, using …
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Molecular Regulation of Mitochondrial Biogenesis in Exercised and Fasted Human Skeletal Muscle: an Examination of Emerging Regulatory Protein
The transcriptional co-activator PGC-1alpha is widely accepted as the “master regulator” of mitochondrial biogenesis – an increase in mitochondrial content – and much research has been devoted to understanding PGC-1alpha's role in mitochondrial remodeling. However, several studies have demonstrated …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… activated receptor gamma coactivator-1 (PGC-1α) and other transcription factors that act as accessory factors in T3 actions. </p> <p>Thyroid hormone receptors (TRα or TRβ) are part of the nuclear receptor family and have been implicated in the induction of many genes by T3. The nuclear …
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Signalling and transcriptional regulation of human primordial germ cell specification
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation human embryos, which are inaccessible for direct investigation. This process can however be modelled using human embryonic stem cells (hESCs) for in vitro derivation of human PGC-like cells (hPGCLCs). …
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