Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?

Pharyngocutaneous fistula is a common complication of total laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in patients undergoing primary total laryngectomy. The incidence of pharyngocutaneous fistula was recorded.

Grantor dc:publisher.institution

Division of Otorhinolaryngology

Year dc:date.issued

2013

Author dc:creator

• Stephenson, Katherine Anna

Advisor dc:contributor.advisor

• Fagan, Johan

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2904

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2904