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We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in patients undergoing primary total laryngectomy. 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We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in patients undergoing primary total laryngectomy. The incidence of pharyngocutaneous fistula was recorded."]},{"key":"dc:title","label":"Title","values":["Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?"]}]}],"canonical_facts":{"dc:contributor.advisor":["Fagan, Johan"],"dc:creator":["Stephenson, Katherine Anna"],"dc:date.accessioned":["2014-07-28T14:30:18Z"],"dc:date.available":["2014-07-28T14:30:18Z"],"dc:date.issued":["2013"],"dc:description":["Includes abstract.","Includes bibliographical references."],"dc:description.abstract":["Pharyngocutaneous fistula is a common complication of total laryngectomy. We hypothesised that perioperative proton pump inhibitor (PPI) treatment could reduce the incidence of pharyngocutaneous fistulae. This prospective placebo-controlled double-blind randomised controlled trial compared PPI treatment (14 days enteral omeprazole) with a placebo in patients undergoing primary total laryngectomy. The incidence of pharyngocutaneous fistula was recorded."],"dc:identifier.uri":["http://hdl.handle.net/11427/2904"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Otorhinolaryngology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Do proton pump inhibitors reduce the incidence of pharyngocutaneous fistulae following total laryngectomy?"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MMed"]},"updated_at":"2026-07-22T22:22:55Z"}