The first-pass extraction of pindolol in comparison with propranolol in rat liver

Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by means of an isolated rat liver perfusion model.

Grantor dc:publisher.institution

Division of Clinical Pharmacology

Year dc:date.issued

1979

Author dc:creator

• Basset, Helen Margaret

Advisor dc:contributor.advisor

• Folb, Peter I

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/27659

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/27659