A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)

Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, thereby preventing complementmediated opsonisation of virus, antibody-mediated lysis of infected cells and migration of inflammatory cells into the site of infection. VCP also possesses heparin binding sites.

Grantor dc:publisher.institution

Division of Virology

Year dc:date.issued

2007

Author dc:creator

• Paulsen, Janis

Advisors dc:contributor.advisor

• Douglass, Nicola
• Williamson, Anna-Lise

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2733

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2733