Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Complement Activation"”.
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Complement activation and effector pathways in ischaemia reperfusion injury and at the interface with adaptive immunity
… failure. Renal IRI is known to be mediated by complement, which causes direct injury to the transplant and stimulates the adaptive immune response against transplant antigens. However uncertainty exists as to the exact trigger mechanisms of complement activation in this situation, and to the …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
… (Aβ) protein. Aβ activates the classical complement pathway by binding to C1q that may sustain inflammation, hamper Aβ clearance and therefore promote accumulation of Aβ deposits in the brain and affect the integrity of the blood-brain barrier. Depending on context, binding of apoE to C1q …
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A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)
… (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. It has been shown to inhibit both the alternative and classical pathways of complement activation by binding to the proteins C3 and C4, …
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The regulation of allergic airway disease by type V collagen-induced tolerance
Rationale: Tissue remodeling and complement activation are asthma hallmarks. Type V collagen [col(V)], a cryptic antigen, becomes exposed during lung remodeling. IL-17 is key to anti-col(V) immunity, and regulates complement activation. We have reported that col(V)-induced tolerance down regulates …
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Effect of Sialylation of Histophilus somni Lipooligosaccharide on Virulence and Resistance to Host Defenses
… of sialylation of Histophilus somni LOS on complement-mediated killing, binding of complement factor H (which converts C3b to inactive C3b (iC3b) and inhibit the alternative complement pathway) to the bacteria, complement activation by the LOS, and phagocytosis and killing of the bacteria by …
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Complement in Disease - Extracellular Proteins as Complement Regulators
Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family …
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The Role of Complement in Ischemic Heart Disease in Type 2 Diabetes Mellitus
… recognized by reactive oxidant production, complement activation, and leukocyte-endothelial cell adhesion, among others. Complement activation plays an important role in the inflammatory response and is involved in the manifestation of I/R injury in the non-diabetic heart, and is a potent …
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THE ROLE OF BACTERIAL AMYLOID FIBRILS IN ESCHERICHIA COLI COMPLEMENT RESISTANCE
… factors which make them more resistant to the complement system. The bacterial amyloid fibril, curli, functions in bacterial adherence and the formation of biofilm. Curli-producing parental and curli-deficient mutant E. coli was compared in its survival to human complement, using in vitro serum …
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Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells
… treatment for PTD. We tested the hypothesis that complement activation plays a role in cervical remodeling and PTD. We studied cervical remodeling at term.</p> <p>We studied two mouse models of inflammation-induced PTD. The first model was induced by vaginal administration of lipopolysaccharide …
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Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System
… in hemostasis, has been shown to interact with complement components. However results are contrasting and inconclusive. By studying 20 patients with congenital thrombotic thrombocytopenic purpura (cTTP) who can not cleave VWF multimers due to genetic ADAMTS13 deficiency, we investigated the …
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Engineering Microbubbles with the Buried-Ligand Architecture for Targeted Ultrasound Molecular Imaging
… shown that targeted microbubbles could induce complement activation and reduce their circulation persistence. In order to avoid the undesired immune response, a novel stealth microbubble design that consisted a bimodal poly(ethylene glycol) (PEG) brush layer, named buried-ligand architecture …
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Studies of EHEC and the complement system in renal diseases
… Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium. In order to gain access to the circulation it first damages the intestinal mucosa. The mechanism of damage …
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Evaluation of the in vivo role of vaccinia virus complement control protein (VCP) following renal ischemia
… associated with the accumulation of injurious complement components. The vaccinia virus complement control protein (VCP) has the ability to simultaneously inhibit the classical and the alternative complement pathways by binding to the early components C3b and C4b. The complement component C3 is …
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THE ROLE OF GENETIC VARIANTS OF NON-STRUCTURAL PROTEIN 1 IN DENGUE PATHOGENESIS
… displayed severe symptoms coupled with enhanced complement activation, tissue inflammation and higher lethality. Lipidomics profiling of the purified sNS1 from wild-type and TS-virus revealed that they carried different lipid classes. Interestingly, treatment of human PBMCs with purified sNS1 …
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The role of anaphylatoxins in asthma and airway remodelling
… are proinflammatory polypeptides released during complement activation. They exert their biological functions by interacting with the G protein-coupled receptors, C3aR and C5aR respectively. Activation of the complement system has been implicated in the pathogenesis of many inflammatory diseases …
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Molekulare Klonierung der kritischen Region der Fibronektinglomerulopathie (GFND) auf Chromosom 1q31 und Bewertung von Kandidatengenen
… dieser Region konnte das 'regulator of complement activation gene cluster' (RCA) lokalisiert werden, welches nach der gegenwärtigen Hypothese zur Pathogenese der Erkrankung interessante Kandidatengene enthält. <br> <br>In der vorliegenden Arbeit wurde das YAC-Contig zur Feinkartierung …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
The complement system is an essential branch of the innate immune system and acts as a bridge to the adaptive immune system. It serves as the first line of defense against pathogens, as well as in the clearance of immune complexes and apoptotic cells. Deficiencies in many of the complement …
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The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
… and in vivo. Previous i have implicated the complement system in ANCA vasculitis. Furthermore, TNFot •d neutrophils which have been activated with ANCA in vitro are known to release a >r into the supernatant which causes complement activation in normal serum. This w has yet to be identified, …
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Determinants of Immunity against the Meningococcus
… role for meningococcal specific IgG and complement activation in conferring protection against invasive infections. Here, I reveal that protection can occur in mice lacking either complement or IgG. Protection in the absence of complement relies on high antibody titer and my data suggests …
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The Role of the Complement System in Mousepox Infection
… immunomodulatory virulence factors, including a complement regulatory protein. Ectromelia virus provides a mouse model for human smallpox infection where the virus and the host's immune response have also co-evolved. Using this model, we investigated the role of the complement system in a …
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