Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa

Several studies have shown that patients with low TPMT activity are at risk for severe and potentially fatal haematopoietic toxicity when treated with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression.

Grantor dc:publisher.institution

Division of Chemical Pathology

Year dc:date.issued

2002

Author dc:creator

• Olufadi, Rasaq

Advisors dc:contributor.advisor

• Harley, Eric
• Owen, E P

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/2698

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/2698