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Showing 1 to 20 of 45 for “"Genetic polymorphism"”.
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Genetic polymorphism of the human apolipoproteins A and E
… isoelectric focusing was used to demonstrate the polymorphism of the apolipoproteins E, A-I, A-II and A-IV. Polymorphic forms of apo E were detected after ultracentrifugation of plasma, delipidation of VLDL and isoelectric focusing of the remaining protein. The six common phenotypes, homozygotes E …
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Genetic Polymorphism of Prostanoid Receptors, CRTH2 and TBXA2R in Aspirin Hypersensitivity
… with asthma and atopy, we investigated whether genetic polymorphisms of the TBXA2R gene are associated with AIAU phenotype through a case-control of three study subjects. MATERIALS AND METHODS: The three studies groups 107 patients with AIA, 115 patients with ATA, and 133 normal healthy controls …
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An investigation of genetic polymorphism in association with Type 2 diabetes and metabolic syndrome.
… countries. Various studies have suggested the genetic susceptibility to the disorders. The main aim of the thesis was to investigate the putative association of single nucleotide polymorphisms with Type 2 diabetes (T2D), metabolic syndrome (MetS) and the major components of metabolic syndrome. …
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Genetic Polymorphism Study of Prostaglandin E2 Receptor Subtype EP4 gene (PTGER4) in Aspirin - Intolerant Urticaria
"국문요약 = i 차 례 = iv 그림 차례 = vi 표 차례 = vii 약 어 = viii I. 서 론 = 1 Ⅱ. 재료 및 방법 = 4 A. 프로스타글란딘 E2 수용체(PTGER4)의 단일염기다형성 연관성 연구 = 4 1. 직접염기서열 분석을 이용한 프로스타글란딘 E2 수용체의 단일염기다형성의 조사 = 4 2. 연구 대상 및 표현형 = 5 3. 유전자형 분석 = 5 B. 프로스타글란딘 E2 수용체의 단일염기다형성의 기능적 연구 = 11 1. 세포배양 = 11 2. 역전사 중합효소연쇄반응(RT-PCR)을 이용한 다양한 …
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Genetic polymorphism of alpha s1-casein. Feeding strategies to optimize productive performances of dairy goat with different genotype.
… the effects of diet and alpha s1-casein genetic polymorphism on the productive performances of dairy goat are discussed separately. Besides to cover a lack of scientific knowledge on this topic, we think that to study the effect of interaction between dietary and genetic factors on …
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
… function, on Tregs is determined by the genetic polymorphism of the CD39 gene (at position rs_10748643), where its expression may be low (AA-genotype), medium (AG-genotype) or high (GG-genotype). Hence, CD39 genetic polymorphism may significantly determine CD39+ Treg function and …
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Screening for thiopurine s-methyltransferase (TPMT) gene mutations in South Africa
… with conventional doses of thiopurine drugs. Genetic polymorphism in the TPMT gene is an important determinant of mercaptopurine toxicity. Patients with mutations in the TPMT gene have a less efficient methylation process, and are therefore, predisposed to severe myelosuppression.
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Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
… disease, determined by the interaction of genetic factors with environmental risk factors. In South Africa, OSCC is a major malignancy occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research group have reported that genetic polymorphism of …
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Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
The term "pharmacogenetics" has been defined as the scientific study of inherited factors that affect the human drug response. Many pharmacogenetie studies have been published since 1995 and have focussed on the principal enzyme family involved in drug metabolism, the cytochrome P450 family, …
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The Genetics of General Cognitive Ability
… reports the results of three studies of the genetics of GCA, conducted with participants from the Minnesota Center for Twin & Family Research (MCTFR). Study #1 (N = 7,100) is a genome-wide association study plus other analyses that exploit genome-wide single-nucleotide polymorphism (SNP) …
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Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
… respiratory disease (AERD). To investigate genetic contribution of ALOX15 in the development of AERD, we performed the genetic association of ALOX15 study in a Korean population. MATERIALS AND METHODS: One hundred-seventy one patients with AERD, 229 patients with aspirin-tolerant asthma …
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Studies on Holkham salts hole : an isolated salt water community with relict features
… alleles and show significantly higher levels of genetic divergence. Several hypotheses relating genetic polymorphism. and environmental conditions have been examined.The findings support Valentine's hypothesis of trophic resource stability and Stenseth's interpretation of the Red Queen …
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Analysis of the Relationship Between Growth Hormone Receptor Polymorphism rs6180 and Craniofacial Morphological Changes Associated with Herbst Appliance Therapy
… growth results from both environmental and genetic factors over time. It would be exciting to isolate genetic factors that influence treatment responses from patients undergoing orthodontic treatment. Genetic genotyping and analysis of orthodontic patients is a new technologic advancement. …
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Investigations on the role of SLP-65 and other B cell signaling proteins in human leukemia
… aberrantly spliced SLP-65 mRNA. In addition, a genetic polymorphism involved in mediating exon recognition was identified. Three of ten patients were deficient for the transcription factor pax-5 involved in regulating SLP-65 expression and one of those patients had aberrant pax-5 mRNA’s lacking …
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Structural Analyses of Murine Histocompatibility Antigens
… to provide some insight into the nature of the genetic polymorphism. In order to carry out these studies, specific anti-H-2 alloantisera were produced. The sera recognized only one H-2 gene product as shown by antibody mediated cytotoxicity and immunoprecipitation assays. The alloantisera also …
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A Gain-of-Function Role of Apolipoprotein E2 in Melanoma Progression
<p>Genetic polymorphism of the secreted lipid transporter apolipoprotein E (APOE) plays important roles in the development of atherosclerosis and Alzheimer's disease. More recently, three common APOE alleles have been implicated as modulators of melanoma progression and survival. Melanoma patients …
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
… respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been shown to affect warfarin response and favorably facilitate warfarin dosing and improve clinical outcomes. However, none of these studies have involved populations from sub-Saharan Africa where the potential …
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RAPD markers for ascochyta resistance, phylogenetic studies and cultivar identification In lentil
… DNA (RAPD) markers were used in three genetic studies in lentil (Lens culinaris Medikus). The first study involved development of RAPD markers linked with genes for resistance to ascochyta blight, caused by Ascochyta fabae f. sp. lentis Gossen et al. Seventy F2-derived F3 (F2:3) lines …
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A study of innate immune and genetic factors that play a role in protecting seronegative blood recipients exposed to hepatitis C
… blood; if so, ii) what innate immune and genetic factors played a role in protecting them from HCV. A total of 8 blood recipients were identified with a confirmed exposure to HCV, but without any serological or virologic evidence of infection. The following were analysed: receptor …
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