Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity

The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine.

Grantor dc:publisher.institution

Department of Anaesthesia

Year dc:date.issued

1998

Author dc:creator

• Reed, Anthony Raddon

Advisor dc:contributor.advisor

• James, Michael F M

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/26985

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/26985