{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/26985"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/26985","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity","abstract":"The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine.","abstract_html":"The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine.","abstract_has_math":false,"creators":["Reed, Anthony Raddon"],"institution":"Department of Anaesthesia","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["James, Michael F M"],"committee_chairs":[],"committee_members":[],"year":1998,"date_issued":"1998","date_published":"1998","updated_at":"2026-07-22T22:23:29Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/26985","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["James, Michael F M"]},{"key":"dc:creator","label":"Author","values":["Reed, Anthony Raddon"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-01-25T13:57:23Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-01-25T13:57:23Z"]},{"key":"dc:date.issued","label":"Date","values":["1998"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Anaesthesia"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MMed"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/26985"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine."]},{"key":"dc:title","label":"Title","values":["Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity"]}]}],"canonical_facts":{"dc:contributor.advisor":["James, Michael F M"],"dc:creator":["Reed, Anthony Raddon"],"dc:date.accessioned":["2018-01-25T13:57:23Z"],"dc:date.available":["2018-01-25T13:57:23Z"],"dc:date.issued":["1998"],"dc:description.abstract":["The results of this study show that in intact rats magnesium produces a more rapid resolution of bupivacaine induced electrophysiological changes than placebo. The improvements are in rhythm and electrical conduction, although this is often at the expense of potentiating the bradycardic effects of bupivacaine toxicity. Whilst the bradycardia remains a problem it is potentially more amenable to therapy than the changes in rhythm and conduction which magnesium sulphate reversed. The opportunity therefore exists to explore the possibility of combining magnesium with a positive chronotrophic agent such as dobutamine."],"dc:identifier.uri":["http://hdl.handle.net/11427/26985"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Anaesthesia"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Magnesium sulphate reversal of established bupivacaine electrophysiological cardiotoxicity"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MMed"]},"updated_at":"2026-07-22T22:23:29Z"}