Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine

Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

1972

Author dc:creator

• Kleynhans, Carl Rudolf

Advisor dc:contributor.advisor

• Warren, F L

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/18379

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/18379