{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/18379"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/18379","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine","abstract":"Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation.","abstract_html":"Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation.","abstract_has_math":false,"creators":["Kleynhans, Carl Rudolf"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Warren, F L"],"committee_chairs":[],"committee_members":[],"year":1972,"date_issued":"1972","date_published":"1972","updated_at":"2026-07-22T22:22:58Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/18379","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Warren, F L"]},{"key":"dc:creator","label":"Author","values":["Kleynhans, Carl Rudolf"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-03-30T07:11:37Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-03-30T07:11:37Z"]},{"key":"dc:date.issued","label":"Date","values":["1972"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/18379"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation."]},{"key":"dc:title","label":"Title","values":["Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine"]}]}],"canonical_facts":{"dc:contributor.advisor":["Warren, F L"],"dc:creator":["Kleynhans, Carl Rudolf"],"dc:date.accessioned":["2016-03-30T07:11:37Z"],"dc:date.available":["2016-03-30T07:11:37Z"],"dc:date.issued":["1972"],"dc:description.abstract":["Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation."],"dc:identifier.uri":["http://hdl.handle.net/11427/18379"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:22:58Z"}