Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'

Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

1987

Author dc:creator

• Ramdohr, Jurgen Ernst

Advisors dc:contributor.advisor

• Green, Ivan Robert
• Yorke, Selwyn

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/15896

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/15896