{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/15896"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/15896","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'","abstract":"Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their \"anti-cancer\" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative.","abstract_html":"Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their "anti-cancer" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative.","abstract_has_math":false,"creators":["Ramdohr, Jurgen Ernst"],"institution":"Department of Chemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Green, Ivan Robert","Yorke, Selwyn"],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-22T22:23:36Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/15896","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Green, Ivan Robert","Yorke, Selwyn"]},{"key":"dc:creator","label":"Author","values":["Ramdohr, Jurgen Ernst"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-12-20T15:42:45Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-12-20T15:42:45Z"]},{"key":"dc:date.issued","label":"Date","values":["1987"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Chemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/15896"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: pages 76-78."]},{"key":"dc:description.abstract","label":"Abstract","values":["Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their \"anti-cancer\" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative."]},{"key":"dc:title","label":"Title","values":["Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'"]}]}],"canonical_facts":{"dc:contributor.advisor":["Green, Ivan Robert","Yorke, Selwyn"],"dc:creator":["Ramdohr, Jurgen Ernst"],"dc:date.accessioned":["2015-12-20T15:42:45Z"],"dc:date.available":["2015-12-20T15:42:45Z"],"dc:date.issued":["1987"],"dc:description":["Bibliography: pages 76-78."],"dc:description.abstract":["Chapter One describes the synthesis of a trifluoroethylnaphtho-1, 4-quinone via a regiospecific trifluoroacetylation of an appropriately substituted naphthalene. Chapter Two describes the synthesis of the methyl ethers of the naturally occurring quinones A and deoxyquinone A for evaluation of their \"anti-cancer\" activity by the National Institutes of Health. In Chapter Three the final few steps of the synthesis of the aphid-derived quinone A' are described. This was made possible by the development of an efficient route for the conversion of a precursor to quinone A' via the corresponding chloro-derivative."],"dc:identifier.uri":["http://hdl.handle.net/11427/15896"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Synthesis of naphtho{2,3-c}pyrans including the aphin-derived quinone A'"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:36Z"}