Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but the mechanisms involved remain unclear. Janus kinase/Signal transducer and activator of transcription 3 (JAK/STAT-3) form part of a recently discovered powerful prosurvival path termed as the Survivor Activating Factor Enhancement (SAFE) pathway. The SAFE pathway plays a critical role in ischaemic preconditioning to promote cell survival but whether activation of STAT-3 is required for S1P preconditioning and ischaemic postconditioning induced cardioprotection is unknown. Hypothesis: Activation of the STAT-3 is required for S1P preconditioning and ischaemic postconditioning.

Grantor dc:publisher.institution

Division of Cardiology

Year dc:date.issued

2011

Author dc:creator

• King, Jonathan Chan

Advisors dc:contributor.advisor

• Lecour, Sandrine
• Opie, Lionel H

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12692

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12692