Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines

Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the type-specific prevention of infection and associated disease. However, the high cost of the vaccines has limited their widespread application, and cytological screening programmes are still required to detect malignant lesions associated with the non-vaccine types, particularly in HIV-infected populations.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2011

Author dc:creator

• Pineo, Catherine

Advisors dc:contributor.advisor

• Rybicki, Ed
• Hitzeroth, Inga

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12240

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12240