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Showing 1 to 20 of 199 for “"Human Papillomavirus"”.
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Human Papillomavirus Infections and Human Papillomavirus Associated Diseases in Nigeria: Distribution, Determinants and Control
Background: Persistent infection with high risk HPV is a necessary but insufficient cause of cervical cancer. Behavioural, viral and host factors modulate the risk of HPV persistence. In this thesis, I explore the role of the vaginal microbiota, a host factor and the presence of multiple HPV …
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Human Papillomavirus Prevalence in Asymptomatic Men
Introduction: Human papillomavirus (HPV) is the sexually transmitted etiologic agent of cervical cancer. While HPV infects both men and women, little is known about HPV infection in men. Specifically, knowledge of the prevalence of type-specific HPV infection and the distribution of these …
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Development of candidate Human papillomavirus vaccines
… novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, …
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Human Papillomavirus Knowledge and Human Papillomavirus Uptake Among U.S. Navy Personnel 18 to 26 Years of Age
<p>High human papillomavirus (HPV) incidence rates occur in the military and are one of the leading medical events in the armed forces. Although there are high HPV rates in uniformed personnel, the U.S. military reports lower vaccination uptake rates than the national average. The HPV vaccine is …
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Characterizing Human Papillomavirus Associated Oral Epithelial Dysplasia
The role of high-risk human papillomavirus (HR-HPV) is well documented in oropharyngeal squamous cell carcinoma and cervical cancer. Although a subset of oral dysplastic lesions have been associated to HPV infection as well, there is currently limited data characterizing these lesions. We …
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Human Papillomavirus vaccination: Immunological and epidemiological studies
… immunological- and epidemiological aspects of human papillomavirus transmission dynamics and its effect on circumcision. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope is defined by the monoclonal antibody H16.V5. To investigate …
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Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis
<p>High-risk human papillomavirus (HPV) is the causative agent of cervical cancer. Integration of the HPV genome into the host genome is a key event in cervical carcinogenesis, with oxidative stress (OS) likely playing a major role in promoting DNA damage, and subsequently, integration. In our …
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Transcriptional Regulation Mediated by Human Papillomavirus E2 Protein
Human papillomaviruses (HPVs) are one of the most common sexually transmitted pathogens in the world. The American Social Health Association reports that there are at least 20 million Americans already infected with HPVs and approximately 5.5 million new cases are reported annually. In HPVs, …
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Pan-Cancer Genomic Characterization of Human Papillomavirus Associated Tumors
<p>Infection with high-risk human papillomavirus (HPV) accounts for nearly all cervical cancers (CESC), a subset of other anogenital squamous cancers, and increasing rates of head and neck squamous cell carcinomas (HNSC), with each cancer type having heterogenous outcomes due to a general lack of …
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Novel intranasal GNRs-DNA vaccines against human papillomavirus infection
Currently licensed HPV vaccines, Cervarix and Gardasil, have been successfulin preventing HPV infection and high-graded cervical intraepithelial neoplasia (CIN2,3) in school girls in the UK and other developed countries. However, their high costshave hindered their wider use in preventing HPV …
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Targeting the human papillomavirus for prevention of cervical cancer
Different types of human papillomavirus (HPV) vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the …
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Human papillomavirus testing and its application in cervical cancer prevention
… relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods …
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Influence of Human Papillomavirus 16 E6 on TRAIL-Mediated Apoptosis
<p>Viruses have developed sophisticated strategies to evade host defenses and facilitate the production and spread of progeny. HPV 16, whose immune evasion activities can contribute to cervical cancer, is a prime example of such a virus. In this study, we examined the influence of HPV 16 E6 on …
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Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines
Human papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of …
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Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines
… cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the …
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Association of the Cervical Intraepithelial Neoplasia and Human Papillomavirus Viral load
"목적: 인유두종 바이러스 (HPV) viral load가 자궁경부 상피내 종양과 어떠한 상관관계가 있는지와 병변의 중증도를 예측하는 인자로서의 유용성을 알아보고자 하였다. 연구대상 및 방법: 2003년 8월부터 2004년 10월까지 자궁경부 세포검사와 HPV DNA test를 함께 시행받은 총 2411명 중 질확대경 하 조직생검 및 수술을 통해 최종 병리조직학적 진단이 내려진 군 (n=259)을 대상으로 viral load 값과 병변의 중증도를 비교하였다. Viral load의 측정은 Hybrid Capture II …
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