The WNT signalling pathway in Ewing sarcoma/primitive neuroectodermal tumour : an immunohistochemical investigation

The WNT pathway is a major developmental pathway that plays an important role in the development of many tumours, including neuroectodermal and bone tumours. Ewing sarcoma (ES) / primitive neuroectodermal tumour (PNET) shows varying degrees of neuroectodermal differentiation and is the second commonest bone malignancy in childhood. A recent study on ES cell lines using RT-PCR analysis and biological response assays suggests that an intact WNT pathway exists in ES and that addition of exogenous WNT ligands enhances cell motility. Based on this we hypothesize that the WNT pathway may play a role in the biology of ES/PNET and we aim to investigate this by immunohistochemical stains on archival tissue.

Grantor dc:publisher.institution

Division of Anatomical Pathology

Year dc:date.issued

2011

Author dc:creator

• Wu, Hue-Tsi

Advisor dc:contributor.advisor

• Govender, Dhiren

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11479

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11479