The relationship between structure and specificity in the plant nitrilases

Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities.

Grantor dc:publisher.institution

Department of Molecular and Cell Biology

Year dc:date.issued

2011

Author dc:creator

• Woodward, Jeremy David

Advisor dc:contributor.advisor

• Sewell, Trevor

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11347

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11347