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Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities.","abstract_has_math":false,"creators":["Woodward, Jeremy David"],"institution":"Department of Molecular and Cell Biology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Sewell, Trevor"],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T01:34:19Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11347","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Sewell, Trevor"]},{"key":"dc:creator","label":"Author","values":["Woodward, Jeremy David"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-05T06:46:57Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-05T06:46:57Z"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Department of Molecular and Cell Biology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11347"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities."]},{"key":"dc:title","label":"Title","values":["The relationship between structure and specificity in the plant nitrilases"]}]}],"canonical_facts":{"dc:contributor.advisor":["Sewell, Trevor"],"dc:creator":["Woodward, Jeremy David"],"dc:date.accessioned":["2015-01-05T06:46:57Z"],"dc:date.available":["2015-01-05T06:46:57Z"],"dc:date.issued":["2011"],"dc:description.abstract":["Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities."],"dc:identifier.uri":["http://hdl.handle.net/11427/11347"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Molecular and Cell Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The relationship between structure and specificity in the plant nitrilases"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-24T01:34:19Z"}