New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria

This thesis was concerned with the design and synthesis of compounds which are either substrate-mimics or inhibitors of MshB, a N-deacetylase involved in the biosynthesis of mycothiol in the Mycobacteria, including M. tuberculosis, the causative agent of TB. Mycothiol is a low molecular weight thiol produced by Mycobacteria as a defense against oxidative stress and xenobiotics, and the enzymes involved in its biosynthesis are postulated to be viable drug targets.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2011

Author dc:creator

• Muganza, Freddy Munyololo

Advisor dc:contributor.advisor

• Gammon, David W

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11048

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11048