The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa

This thesis aimed to address a number of unanswered research questions in Addison's Disease: investigate whether autoimmunity is the predominant cause of Addison's disease in South Africa and if a human leukocyte (HLA) DQ antigen association exists; the extent to which lipids, lipoproteins and biochemical markers of cardiovascular disease are abnormal; the degree to which replacement doses of hydrocortisone are supra-physiological; the impact of glucocorticoid receptor (GCR) polymorphisms on risk factors, markers of cardiovascular disease and replacement doses of hydrocortisone.

Grantor dc:publisher.institution

Department of Medicine

Year dc:date.issued

2011

Author dc:creator

• Ross, Ian Louis

Advisor dc:contributor.advisor

• Levitt, Dinky

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10862

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10862