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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"hydrocortisone"”.
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Synthesis and pharmacological evaluation of conformationally constrained models of hydrocortisone
<p>The study of conformation in drug action can be approached from two directions, (i) that of the drug, and (ii) that of the receptor. Since the problem of elucidating the biologically active conformation of drug molecules has been extensively studied and is very well reviewed<sup>1,2</sup>, it …
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ROLE OF HYDROCORTISONE 21-HEMISUCCINATE DURING CARRAGEENAN-INDUCED ACUTE INFLAMMATION
… used as a bioassay model to study the effects of hydrocortisone 21-hemisuccinate on acute inflammation induced by carrageenan. Intravenous injection of hydrocortisone 21-hemisuccinate resulted in a significant drop in circulating blood leucocytes, with a parallel decrease in the adhesiveness of …
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The Effects of Hydrocortisone And Caffeine on Memory for Word Lists
<p>Hydrocortisone has frequently been hypothesized to increase arousal. This hypothesis was primarily based on the findings of increased adrenal size in animals who had been exposed to stressful conditions and the enhancement or impairment in cognitive abilities of humans depending on dose. There …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… anti-inflammatory drugs; aspirin, ibuprofen and hydrocortisone, in their bulk and nano forms were evaluated on peripheral blood lymphocytes of healthy donors using the comet assay and the micronucleus assay. In order to determine any anti-cancer effects, these agents were also tested in …
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Hydrocortison in Stressdosierung, traumatische Erinnerungen und Posttraumatische Belastungsstörung
… whether exogenously administered stress doses of hydrocortisone during the perioperative period of CS reduces the long-term incidence of chronic stress and PTSD symptoms. Methods: Patients (n=91) were prospectively randomized to receive either stress doses of hydrocortisone or standard treatment …
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Aspergillosis: interactions of Aspergillus fumigatus andHuman Airway Cells
… on suppressing body’s defence mechanism. As hydrocortisone is present during Aspergillus infection, understanding the ability of the fungus to perceive this host-factor enhances the understanding of A. fumigatus interaction with the host within the host environment. Previous reports have …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… of two of hydrophobic steroid drugs: hydrocortisone and prednisolone were produced. Nanosuspensions were prepared using a bottom-up approach: the anti-solvent precipitation method using microfluidic reactors. Surface modification was carried out on these nanosuspensions using cationic …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… during differentiation. We hypothesized that hydrocortisone (HC) is necessary for in vitro differentiation of airway basal cells into a pseudostratified epithelium with ciliated and secretory surface cells. Additionally, we hypothesized a role for HC in the development of normal …
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Συστηματική ανασκόπηση για τα βραδείας και παρατεταμένης αποδέσμευσης σκευάσματα υδροκορτιζόνης (modified-release hydrocortisone, MR-HC) στη θεραπεία της κλασικής μορφής συγγενούς υπερπλασίας των επινεφριδίων
ΕΙΣΑΓΩΓΗ: Η Συγγενής Υπερπλασία των Επινεφριδίων (ΣΥΕ) λόγω ανεπάρκειας της 21-υδροξυλάσης είναι μία γενετική νόσος που κληρονομείται με αυτοσωματικό υπολειπόμενο χαρακτήρα. Η ΣΥΕ χαρακτηρίζεται από ανεπαρκή παραγωγή κορτικοστεροειδών και αλατοκορτικοειδών και υπερπαραγωγή επινεφριδιακών …
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The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa
… the degree to which replacement doses of hydrocortisone are supra-physiological; the impact of glucocorticoid receptor (GCR) polymorphisms on risk factors, markers of cardiovascular disease and replacement doses of hydrocortisone.
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Studies on the Formulation of Topical Corticosteroids
The stabilities of betamethasone-17-valerate and hydrocortisone-17-butyrate have been investigated. It has been shown that the 17-esters undergo acyl migration to the 21-isomers. These 21-isomers hydrolyse to the free alcohols which further degrade to other products. In order to elucidate the …
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Effects of Glucocorticoids and Limited Nursing on the Digestive Enzyme Ontogeny and Growth of Nursing Piglets (Maltase, Sucrase, Lactase, Amylase, Acth)
… to evaluate the inductive capacity of exogenous hydrocortisone (HYD) and adrenocorticotropic hormone (ACTH) on the developing carbohydrate digestive enzymes and growth rate of nursing piglets. The response of these enzymes to increased creep feed consumption, produced by partial weaning, was also …
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Discovering the biological and clinical implications of modulating glucocorticoid action using metabolomic profiling of human plasma samples
… low or high doses of insulin, plussuch a dose of hydrocortisone as to achieve low, medium or high plasma cortisollevels. Finally, plasma samples were also obtained from 119 patients with CAHreceiving standard clinical care. Liquid chromatography-mass spectrometry wasthen employed for the …
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Albumin metabolism following partial hepatectomy in the rat
… following partial hepatectomy. 4. The effect of hydrocortisone on the albumin synthesis rate following partial hepatectomy. 5. The effect of partial hepatectomy on the albumin catabolic rate.
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The role of thyroid and steroid hormones in maturation of the adreline-sensitive reabsorptive mechanism of the fetal lung
… absorption is first seen. Co-infusion of T₃ and hydrocortisone showed that these 2 hormones have a powerful synergistic effect on the absorption mechanism. Within a few hours of infusion of these 2 hormones to immature fetuses, a reabsorptive response to adrenaline similar to that normally seen …
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Investigation of a Model for the Study of Digital Perfusion in Equine Laminitis Using an Extract of Black Walnut (Juglans Nigra)
… equine digital vessels in the presence of hydrocortisone. Clinical signs, hematologic and serum biochemical parameters, plasma epinephrine and cortisol concentrations, distribution of digital capillary perfusion, lesions, and the efficacy of a single dose of prazosin were assessed for …
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Development of supercritical processes for particle coating / encapsulation with polymers
… of poly lactide-co-glycolide (PLGA 50/50) and hydrocortisone were selected as the coating material and the model drug, respectively. The hydrocortisone particles were successfully coated with PLGA. At higher polymer loading ratios, the coated drug particles showed sustained release behavior. …
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The targeting of corticosteroids to inflamed tissues
… tissues by both the oral and intravenous routes. Hydrocortisone (HC)-loaded albumin microspheres were prepared by three different methods, by direct incorporation of HC within the particles, by indirect incorporation of HC by the enzymatic conversion of hydrocortisone-21-phosphate (H-21-P) to HC …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… products is tested using three steroids (hydrocortisone, prednisolone and budesonide). Arrested antisolvent nanoprecipitation using ethanol (solvent) and water (antisolvent) was conducted within the microreactors. To enable experimental design for the microreactor studies, solubility …
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